Neurobiol Dis. 2005 Oct;20(1):12-26. Increase of C1q biosynthesis in brain microglia and macrophages during lentivirus infection in the rhesus macaque is sensitive to antiretroviral treatment with 6-chloro-2',3'-dideoxyguanosine.
Source
Department of Molecular Neuroscience, Institute of Anatomy and Cell Biology, Philipps University, Robert-Koch-Str. 8, 35033 Marburg, Germany.
Abstract
Complement activation in the brain contributes to the pathology of neuroinflammatory and neurodegenerative diseases such as neuro-AIDS. Using semiquantitative in situ hybridization and immunohistochemistry, we observed an early and sustained increase in the expression of C1q, the initial recognition subcomponent of the classical complement cascade, in the CNS during simian immunodeficiency virus (SIV) infection of rhesus macaques.
Cells of the microglial/macrophage lineage were the sources for C1q protein and transcripts.
- Mikroglia/ makrofagi linjan soluissa on komplementin C1q proteiinia ja transkriptejä.
C1q expression was observed in proliferating and infiltrating cells in SIV-encephalitic brains.
All SIV-positive cells were also C1q-positive.
- SIV-positiivisissa soluissa oli Cq1 positiivisuus.
Treatment with the CNS-permeant antiretroviral agent 6-chloro-2',3'-dideoxyguanosine decreased C1q synthesis along with SIV burden and focal inflammatory reactions in the brains of AIDS-symptomatic monkeys.
- C1q komplementtitekijän synteesin vähenemä antiretroviraalisesta lääkityksestä vähensi SIV viruskuormitusta ja paikallistulehdusta aivoissa.
Thus, activation of the classical complement arm of innate immunity is an early event in neuro-AIDS and a possible target for intervention.
- Tutkijat ovat sitä mieltä että neuro-AIDS:in varhaistapahtumissa oleva klassisen komplementtilinjan aktivoaatio on mahdollinen interventiokohde.
- PMID:
- 16137563
- [PubMed - indexed for MEDLINE]
Inga kommentarer:
Skicka en kommentar