RIG-1 on sama kuin DDX58 , RNA helikaasi, joka tunnistaa erilaisia virusRNA rakenteita solussa

Hienosäätöä tulee RIG1:iin  monista sinkkiproteiineista ja niitä säätelemällä  taas inflammasomit vaikuttavat  tähän RNA- helikaasiin, joka voisi  tunnistaa  soluun tulleen  viruksen RNA:ta. Esim NLRP12 johtaa  RIG-1 molekyyliä silppuriin   ja  NNLRC5  estää RIG-1- MAVS  ineraktion.

Aliases for DDX58 Gene

• GeneCards Symbol: DDX58 ²
• DExD/H-Box Helicase 58 ^{2 3 5}
• RIG-I ^{2 3 4 5}
• RIG-1 ^{2 4 5}
• RIG1 ^{2 3 5}
• Antiviral Innate Immune Response Receptor RIG-I ^{3 4}
• DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 ^{2 3}
• Retinoic Acid-Inducible Gene 1 Protein ^{3 4}
• Retinoic Acid-Inducible Gene I Protein ^{3 4}
• ATP-Dependent RNA Helicase DDX58 ^{3 4}
• DEAD Box Protein 58 ^{3 4}

• RNA Helicase RIG-I ^{2 3}
• DKFZp434J1111 ^{2 5}
• FLJ13599 ^{2 5}
• RLR-1 ^{3 4}
• DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide ³
• Probable ATP-Dependent RNA Helicase DDX58 ³
• Retinoic Acid Inducible Gene I ²
• RIG-I-Like Receptor 1 ⁴
• EC 3.6.4.13 ⁴
• SGMRT2 ³
• RIGI ³

External Ids for DDX58 Gene

 

Entrez Gene Summary for DDX58 Gene

• DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of the antiviral innate immune response. Mutations in this gene are associated with Singleton-Merten syndrome 2. [provided by RefSeq, Aug 2020]

GeneCards Summary for DDX58 Gene

DDX58 (DExD/H-Box Helicase 58) is a Protein Coding gene. Diseases associated with DDX58 include Singleton-Merten Syndrome 2 and Singleton-Merten Syndrome. Among its related pathways are Metabolism of proteins and SARS-CoV-2 Infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is ENSG00000288684.

UniProtKB/Swiss-Prot Summary for DDX58 Gene

• Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and pro-inflammatory cytokines (PubMed:15208624, PubMed:16125763, PubMed:15708988, PubMed:16127453, PubMed:16153868, PubMed:17190814, PubMed:18636086, PubMed:19122199, PubMed:19211564, PubMed:29117565, PubMed:28469175, PubMed:31006531). Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments (PubMed:15208624, PubMed:15708988). The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms (PubMed:28469175, PubMed:31006531).
  (Kommentti RNF135  RING zinc finger-proteiini omaa muita nimiä:L13, MMFD, REUL, Riplet)
  
   
  Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons (PubMed:28469175, PubMed:31006531). 
   
  Ligands include 5'-triphosphorylated ssRNAs and dsRNAs but also short dsRNAs (<1 kb in length) (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). 
   Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus (RSV)  and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV) (PubMed:21616437, PubMed:21884169). It also detects rotaviruses and reoviruses (PubMed:21616437, PubMed:21884169).
   Detects and binds to SARS-CoV-2 RNAs which is inhibited by m6A RNA modifications (Ref.65).
   Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV) (PubMed:19631370). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration.

  • DDX58_HUMAN,O95786