Recent advances in human flavivirus vaccines.
Abstract
Dengue
(DENV), West Nile (WNV) and Zika (ZIKV) viruses are
mosquito-transmitted flaviviruses that cause thousands of human deaths
and millions of illnesses each year. In the last decades, epidemic
outbreaks of all three flaviviruses emerged and caused a major health
and economical problem in many parts of the world. The increasing and
expanding burden of flaviviruses has highlighted the need for effective
human vaccines against
all three viruses. This review provides an overview of the recent
progress in DENV, WNV and ZIKV vaccines development with specific focus
on candidates in human clinical development.
Copyright © 2017 Elsevier B.V. All rights reserved.
- PMID:
- 28486135
- DOI:
- 10.1016/j.coviro.2017.04.002
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