HIV-1 virus ottaa vakvasti huomioon solunsisäisen immuniteetin. Vpu ja Vif.

HIV- 1 virus on kehittänyt evoluutiossa   aivan spesifiset aseet  ihmiskehon  solunsisäisiä  puolustavia tekijöitä vastaan 

kuten  Vif, joka  johtaa APOBEC3 molekyylit proteiinisilppuriin ettei niitä tulisi mukaan uusiin virioneihin,

 sekä Vpu- proteiinin, ettei Tetheriini estäisi  uusien virionien vapautumista. 

LÄHDE: 

Methods Mol Biol. 2014;1087:135-58. doi: 10.1007/978-1-62703-670-2_12. HIV-1 Accessory Proteins: Vpu and Vif.

Andrew A, Strebel K.

Source

Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Abstract

HIV-1 Vif and Vpu are accessory factors involved in late stages of viral replication. Vif regulates viral infectivity by preventing virion incorporation of APOBEC3G and other members of the family of cytidine deaminases, while Vpu causes degradation of CD4 and promotes virus release by functionally inactivating the host factor BST-2 (Tetherin) . This chapter described techniques used for the characterization of Vif and Vpu and their functional interaction with host factors. Many of the techniques are, however, applicable to the functional analysis of other viral proteins.

PMID:

24158820

[PubMed - in process]