Syöpäpotilaan röntgenhoito keuhkoa koskevalle alueelle ei johtanut tavallista enempiin vaikutuksiin Covid-19:n vaikutuksesta.

 Osassa syöpiä annetaan röntgenhoitoa, joka osuu keuhkoaluelle. Tässä tutkimuksessa  selvitettiin paheneekin tavallisesti todetut  vaikutukset kuten säteilyn aiheuttama  pneumoniitti ja  keuhkoa suojaaviin surfaktantteihin kohdistuva vaikutus. Tuloksen mukaan  Covid-19 tilanne   ei pahentanut pneumoniittia eikä surfaktanttien  proteiinipitoisuuksissa  ei  tapahtunut äkillisiä muutoksia. Tällaista tutkimusta ei ollut aiemmin tehty.

 DOI: 10.1111/1759-7714.14677 

ORIGINAL ARTICLE

Open Access

Coronavirus disease 2019 (COVID-19) in patients before, during, or after lung irradiation, and serum SP-A and SP-D levels

Naoya Ishibashi, Toshiya Maebayashi, Takuya Aizawa, Masakuni Sakaguchi, Masahiro Okada

First published: 30 September 2022

https://doi.org/10.1111/1759-7714.14677

Sections

The correlation between COVID-19 and RT has not been determined to date and remains a clinical question. The aim of this study was to evaluate coronavirus disease 2019 (COVID-19) pneumonia before, during, and after radiation therapy (RT) regarding the radiation doses, radiation pneumonitis, and surfactant protein levels.

Methods

We evaluated patients diagnosed with COVID-19 before, during, or after RT for the lung between August 2020 and April 2022. In patients with breast cancer, the RT dose to the ipsilateral lung was determined. In all other patients, bilateral lung RT doses were determined. Patients diagnosed with COVID-19 after RT were evaluated to determine whether radiation pneumonitis had worsened compared with before RT. The serum levels of the surfactant proteins SP-A and SP-D were measured before, during, and after RT.

Results

The patients included in the study comprised three men (27.3%) and eight women (72.7%). The primary cancer sites were the breast (n = 7; 63.7%), lung (n = 2; 18.1%), esophagus (n = 1; 9.1%), and tongue (9.1%). COVID-19 was diagnosed before RT in four patients, during RT in two patients, and after RT in five patients. Six (54.5%) patients developed COVID-19 pneumonia. Radiation pneumonitis grade ≥2 was not identified in any patient, and radiation pneumonitis did not worsen after RT in any patient. No rapid increases or decreases in SP-A and SP-D levels occurred after the diagnosis of COVID-19 in all patients regardless of RT timing.

Conclusions

COVID-19 did not appear to result in lung toxicity and surfactant protein levels did not change dramatically.