PLoS One. 2014 Jun 11;9(2):e98569. doi: 10.1371/journal.pone.0098569. eCollection 2014.Discovery and characterization of distinct simian pegiviruses in three wild African Old World monkey species.
Sibley SD1, Lauck M2, Bailey AL2, Hyeroba D3, Tumukunde A3, Weny G3, Chapman CA4, O'Connor DH5, Goldberg TL6, Friedrich TC7.
Abstract
Within the Flaviviridae, the recently designated genus Pegivirus
has expanded greatly due to new discoveries in bats, horses, and
rodents. Here we report the discovery and characterization of three
simian pegiviruses (SPgV) that resemble human pegivirus
(HPgV) and infect red colobus monkeys (Procolobus tephrosceles),
red-tailed guenons (Cercopithecus ascanius) and an olive baboon (Papio
anubis). We have designated these viruses SPgVkrc, SPgVkrtg and
SPgVkbab, reflecting their host species' common names, which include
reference to their location of origin in Kibale National Park, Uganda.
SPgVkrc and SPgVkrtg were detected in 47% (28/60) of red colobus and 42%
(5/12) red-tailed guenons, respectively, while SPgVkbab infection was
observed in 1 of 23 olive baboons tested. Infections were not associated
with any apparent disease, despite the generally high viral loads
observed for each variant. These viruses were monophyletic and equally
divergent from HPgV and pegiviruses previously identified in chimpanzees
(SPgVcpz). Overall, the high degree of conservation of genetic features
among the novel SPgVs, HPgV and SPgVcpz suggests conservation of
function among these closely related viruses. Our study describes the
first primate pegiviruses detected in Old World monkeys, expanding the
known genetic diversity and host range of pegiviruses and providing
insight into the natural history of this genus.PMID:24918769[PubMed - in process]PMCID:PMC4053331
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