KEAP1-NRF2 ja HIF1a. PubMed haku, 4 vastausta

 

Hypoxia-inducible factor-1 as targets for neuroprotection : from ferroptosis to Parkinson's disease.

Wang C, Lv S, Zhao H, He G, Liang H, Chen K, Qu M, He Y, Ou C. Neurol Sci. 2025 Mar;46(3):1111-1120. doi: 10.1007/s10072-024-07832-x. Epub 2024 Oct 28. PMID: 39466326 Review.

RESULTS: HIF-1alpha mediated ferroptosis through oxidative stress and GPX4-GSH system. HIF-1alpha mediates ferroptosisthrough Keap1-Nrf2-ARE, Grx3 and Grx4. HIF-1alpha mediates ferroptosis through iron metabolism. ...

2

NRF2 and Hypoxia-Inducible Factors: Key Players in the Redox Control of Systemic Iron Homeostasis.

Duarte TL, Talbot NP, Drakesmith H. Antioxid Redox Signal. 2021 Aug 20;35(6):433-452. doi: 10.1089/ars.2020.8148. Epub 2020 Nov 10. PMID: 32791852 Review.

This review analyzes the roles of key oxygen-sensing pathways in cellular and systemic regulation of iron homeostasis; specifically, the prolyl hydroxylase domain (PHD)/hypoxia-inducible factor (HIF) and the Kelch-like ECH-associated protein 1/NF-E2 p45-related factor 2 (KEAP1 …

3

MicroRNA miR-24-3p Reduces Apoptosis and Regulates Keap1-Nrf2 Pathway in Mouse Cardiomyocytes Responding to Ischemia/Reperfusion Injury.

Xiao X, Lu Z, Lin V, May A, Shaw DH, Wang Z, Che B, Tran K, Du H, Shaw PX. Oxid Med Cell Longev. 2018 Dec 2;2018:7042105. doi: 10.1155/2018/7042105. eCollection 2018. PMID: 30622671 Free PMC article.

4

KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplants.

Ke B, Shen XD, Zhang Y, Ji H, Gao F, Yue S, Kamo N, Zhai Y, Yamamoto M, Busuttil RW, Kupiec-Weglinski JW. J Hepatol. 2013 Dec;59(6):1200-7. doi: 10.1016/j.jhep.2013.07.016. Epub 2013 Jul 16. PMID: 23867319 Free PMC article.

BACKGROUND & AIMS: The Keap1-Nrf2 signaling pathway regulates host cell defense responses against oxidative stress and maintains the cellular redox balance. METHODS: We investigated the function/molecular mechanisms by which Keap1-Nrf2 complex may …