DENGUE2 infektion, P. falciparum malarian ja Borrelian invaasiota ja disseminaatiota lisää plasminogeenin pilkkoutumistuote plasmiini

 https://www.uniprot.org/uniprotkb/P00747/entry#function

Olen katsomassa plasminogeenin  pilkkoutuistuotteita plasmiini ja angiostatiini. Sivumennen huomaan maininnan dengue2 virustulehduksesta . 

 

Function

function

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1, C4 and C5 (PubMed:6447255).
Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells

Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.

(Microbial infection) ENO/enoloase from parasite P.falciparum (strain NF54) interacts with PLG present in the mosquito blood meal to promote the invasion of the mosquito midgut by the parasite ookinete (PubMed:21949403).
The catalytic active form, plasmin, is essential for the invasion of the mosquito midgut (PubMed:21949403).

(Microbial infection) Binds to OspC on the surface of B.burgdorferi cells, possibly conferring an extracellular protease activity on the bacteria that allows it to traverse host tissue.

(Microbial infection) Interacts with dengue virus type 2 particles (PubMed:31726374).
Enhances dengue virus type 2 infection in Aedes aegypti mosquito midgut by increasing midgut internalization, resulting in higher infection rates and viral dissemination in mosquitoes (PubMed:31726374).

Miscellaneous

Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot.

Catalytic activity

Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.

EC:3.4.21.7 (UniProtKB | ENZYME

| Rhea

)

Activity regulation

Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin. Activated with catalytic amounts of streptokinase. Plasmin activity inhibited by SERPINE2.

Features

Showing features for site, binding site, active site.