TLE1 ,(9q21.32),Transducin-Like Enhancer Protein 1
https://www.genecards.org/cgi-bin/carddisp.pl?gene=TLE1&keywords=TLE1
Aliases for TLE1 Gene
TLE Family Member 1, Transcriptional Corepressor 2 3 5
Transducin-Like Enhancer Of Split 1 (E(Sp1) Homolog, Drosophila) 2 3
Enhancer Of Split Groucho-Like Protein 1 3 4
Transducin Like Enhancer Of Split 1 2 3
Transducin-Like Enhancer Protein 1 3 4
ESG1 3 4
Enhancer Of Split Groucho 1 2
E(Sp1) Homolog 4
GRG1 3
ESG 3
TLE1 (TLE Family Member 1, Transcriptional Corepressor) is a Protein Coding gene.
Diseases associated with TLE1 include Glomus Tumor and Tibial Adamantinoma.
Among its related pathways are Signaling by Wnt and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
Gene Ontology (GO) annotations related to this gene include identical protein binding and transcription factor binding.
An important paralog of this gene is TLE4.TLE Family Member 1, Transcriptional Corepressor 2 3 5
Transducin-Like Enhancer Of Split 1 (E(Sp1) Homolog, Drosophila) 2 3
Enhancer Of Split Groucho-Like Protein 1 3 4
Transducin Like Enhancer Of Split 1 2 3
Transducin-Like Enhancer Protein 1 3 4
ESG1 3 4
Enhancer Of Split Groucho 1 2
E(Sp1) Homolog 4
GRG1 3
ESG 3
UniProtKB/Swiss-Prot Summary for TLE1 Gene
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. TLE1_HUMAN,Q04724
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. TLE1_HUMAN,Q04724
Protein attributes for TLE1 GeneSize: 770 amino acids Molecular mass: 83201 Da
Quaternary structure: Homooligomer and heterooligomer with other
family members. Binds LEF1, RUNX1, RUNX3, FOXA2, KDM6A, UTY, histone H3,
HESX1, ESRRG and the NF-kappa-B subunit RELA. Interacts with HES1 (via
WRPW motif). Interacts with SIX3. Interacts with EFNB1.
Post-translational modifications for TLE1 Gene
Phosphorylated, probably by CDK1. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1.
Phosphorylated, probably by CDK1. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1.
Ubiquitinated by XIAP/BIRC4.
Modification sites at PhosphoSitePlus Modification sites at neXtProt
Modification sites at PhosphoSitePlus Modification sites at neXtProt
TLE3 (15q23)Transducin-Like Enhancer Protein 3
https://www.genecards.org/cgi-bin/carddisp.pl?gene=TLE3&keywords=TLE3
https://www.genecards.org/cgi-bin/carddisp.pl?gene=TLE3&keywords=TLE3
Aliases for TLE3 Gene
This gene encodes a transcriptional co-repressor
protein that belongs to the transducin-like enhancer family of
proteins. The members of this family function in the Notch signaling
pathway that regulates determination of cell fate during development.
Expression of this gene has been associated with a favorable outcome to
chemotherapy with taxanes for ovarian carcinoma. Alternate splicing
results in multiple transcript variants. Additional alternatively
spliced transcript variants of this gene have been described, but their
full-length nature is not known. [provided by RefSeq, Sep 2013]
TLE Family Member 3, Transcriptional Corepressor
2
3
5
Transducin-Like Enhancer Of Split 3 (E(Sp1) Homolog, Drosophila) 2 3
Enhancer Of Split Groucho-Like Protein 3 3 4
Transducin Like Enhancer Of Split 3 2 3
Transducin-Like Enhancer Protein 3 3 4
ESG3 3 4
Transducin-Like Enhancer Of Split 3, Homolog Of Drosophila E(Sp1) 3
Transducin-Like Enhancer Of Split 3 Short Isoform 3
Enhancer Of Split Groucho 3 3
HSALNG0106903 167
HSALNG0106901 167
Lnc-UACA-6 168
HsT18976 3
KIAA1547 4
GRG3 3
ESG 3
Transducin-Like Enhancer Of Split 3 (E(Sp1) Homolog, Drosophila) 2 3
Enhancer Of Split Groucho-Like Protein 3 3 4
Transducin Like Enhancer Of Split 3 2 3
Transducin-Like Enhancer Protein 3 3 4
ESG3 3 4
Transducin-Like Enhancer Of Split 3, Homolog Of Drosophila E(Sp1) 3
Transducin-Like Enhancer Of Split 3 Short Isoform 3
Enhancer Of Split Groucho 3 3
HSALNG0106903 167
HSALNG0106901 167
Lnc-UACA-6 168
HsT18976 3
KIAA1547 4
GRG3 3
ESG 3
GeneCards Summary for TLE3 Gene
TLE3 (TLE Family Member 3, Transcriptional Corepressor) is a Protein Coding gene.
Diseases associated with TLE3 include Chromosome 1Q21.1 Duplication Syndrome.
Among its related pathways are Signaling by Wnt and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
An important paralog of this gene is TLE4.
UniProtKB/Swiss-Prot Summary for TLE3 Gene
Transcriptional corepressor that binds to a
number of transcription factors. Inhibits the transcriptional activation
mediated by CTNNB1 and TCF family members in Wnt signaling. The effects
of full-length TLE family members may be modulated by association with
dominant-negative AES (By similarity).
Protein attributes for TLE3 Gene
https://www.sciencedirect.com/science/article/abs/pii/S037811190000161X
https://doi.org/10.1016/S0378-1119(00)00161-X
Säästin tämän kirjoituksen WIF1 mappiin, jossa on WDR proteiinit , niitä on paljon yli 200. tämä on TLE .perhettä WDR- tyyppiä transdusiineja.
Size:772 amino acids. Molecular mass: 83417 Da Quaternary structure:Homotetramer and heterooligomer with other
family members. Binds LEF1, TCF7 and TCF7L1 (By similarity). Binds
FOXA2. Interacts with XIAP/BIRC4 and TCF7L2/TCF4. Interacts with TBX18
(via engrailed homology 1 repressor motif), leading to decreased of
TBX18 transcriptional activity.SequenceCaution: Sequence=BAB13373.1; Type=Erroneous initiation; Evidence={ECO:0000305};
TLE5
Aliases for TLE5 Gene
The protein encoded by this gene is similar in
sequence to the amino terminus of Drosophila enhancer of split groucho, a
protein involved in neurogenesis during embryonic development. The
encoded protein, which belongs to the groucho/TLE family of proteins,
can function as a homooligomer or as a heteroologimer with other family
members to dominantly repress the expression of other family member
genes. Three transcript variants encoding different isoforms have been
found for this gene. [provided by RefSeq, Jul 2008]
TLE Family Member 5, Transcriptional Modulator
2
3
4
5
Amino-Terminal Enhancer Of Split 2 3 4
Gp130-Associated Protein GAM 3 4
Groucho-Related Protein 5 3 4
TLE Family Member 5 3 4
Grg-5 3 4
GRG5 3 4
AES 3 4
GRG 3 4
Amino Enhancer Of Split 4
Protein ESP1 4
Protein GRG 4
AES-1 3
AES-2 3
ESP1 3
Amino-Terminal Enhancer Of Split 2 3 4
Gp130-Associated Protein GAM 3 4
Groucho-Related Protein 5 3 4
TLE Family Member 5 3 4
Grg-5 3 4
GRG5 3 4
AES 3 4
GRG 3 4
Amino Enhancer Of Split 4
Protein ESP1 4
Protein GRG 4
AES-1 3
AES-2 3
ESP1 3
GeneCards Summary for TLE5 Gene
TLE5 (TLE Family Member 5, Transcriptional Modulator) is a Protein Coding gene.
Among its related pathways are Signaling by Wnt and Ectoderm Differentiation.
An important paralog of this gene is TLE4.
UniProtKB/Swiss-Prot Summary for TLE5 Gene
Transcriptional corepressor. Acts as dominant
repressor towards other family members. Inhibits NF-kappa-B-regulated
gene expression. May be required for the initiation and maintenance of
the differentiated state. Essential for the transcriptional repressor
activity of SIX3 during retina and lens development.TLE5_HUMAN,Q08117
Review
Groucho/TLE family proteins and transcriptional repression Säästin tämän kirjoituksen WIF1 mappiin, jossa on WDR proteiinit , niitä on paljon yli 200. tämä on TLE .perhettä WDR- tyyppiä transdusiineja. 
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