NIDOVIRALES. SARS-CoV reseptori ihmiskehossa on ACE2

http://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&dopt=default&rn=1&list_uids=59272

 The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]


KOMMENTTI:
Wikipedialähde:
ACE2 entsyymiä koodava geeni on ACE2 ja se sijaitsee X- kromosomissa.

CDC artikkeli:
Sairastuneitten  miesten suhde sairastuneisiin naisiin on 1.6: 1.0.

 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6238a4.htm