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lördag 14 december 2013

NIDOVIRALES. SARS-CoV reseptori ihmiskehossa on ACE2


 The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]

ACE2 entsyymiä koodava geeni on ACE2 ja se sijaitsee X- kromosomissa.

CDC artikkeli:
Sairastuneitten  miesten suhde sairastuneisiin naisiin on 1.6: 1.0.


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