ANXA5 (4q27) on antikoagulantti ja solun fosfotidylseriinin (PS) - tunnistaja . Vertailu hepariiniin.

 Miksi tämä vahva   PS-tunnistaja- antikoagulantti Voiko sitä käyttää  antikoagulanttina?

• Linkki selvittelee asiaa ja vertaa hepariiniin.  Sitaatti tekstin alusta:
  

https://esmed.org/MRA/mra/article/view/113

Sitaatti: 

 "When thrombin is present clotting begins and when there is trauma or inflammation the tissue factor pathway is activated and thrombin is produced. In addition to clot formation this thrombin activates the blood coagulation cascade components that can exponentially increase thrombin production, a feedback cycle that is unsustainable and dangerous and requires control. 

This control is manifested in the prothrombinase and tenase complexes  where two of the thrombin activated cascade components, factors V (Thiagarajan P1, Tait JF) and VIII (Ahmad SS) , are required to adhere to PS on the membranes of activated platelets in order for the cascade to begin.

 These complexes are checkpoints where protein C and the annexin A5 molecule modulate the cascade, protein C by inactivating factors V and VIII and annexin A5 by competing with them for PS access.

 Protein C is activated by thrombin but annexin A5 doesn’t require activation and the mechanism for its increased levels during clotting is not known."

 ( Lähdelinkissä selvitetään tarkemmin! 

•   Minkälainen molekyyli on ANNEXIINI A5?
  

 https://alphafold.ebi.ac.uk/entry/P08758

P08758go to UniProt

Experimental structures

14 structures in PDB for P08758go to PDBe-KB

Biological function

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.go to UniProt

Aliases for ANXA5 Gene

• GeneCards Symbol: ANXA5 ²
• Annexin A5 ^{2 3 4 5}
• CPB-I ^{2 3 4 5}
• PAP-I ^{2 3 4 5}
• Placental Anticoagulant Protein I ^{2 3 4}
• Vascular Anticoagulant-Alpha ^{2 3 4}
• Calphobindin I ^{2 3 4}
• Endonexin II ^{2 3 4}
• Annexin V ^{2 3 4}
• VAC-Alph ^{2 3 5}
• RPRGL3 ^{2 3 5}
• ANX5 ^{3 4 5}

• ENX2 ^{3 4 5}
• Placental Anticoagulant Protein 4 ^{3 4}
• Thromboplastin Inhibitor ^{3 4}
• Anchorin CII ^{3 4}
• Lipocortin V ^{3 4}
• VAC-Alpha ^{3 4}
• Annexin-5 ^{3 4}
• PP4 ^{3 4}
• Epididymis Secretory Protein Li 7 ³
• HEL-S-7 ³
• CBP-I ³