ZIKA virus ja keskushermsoton kehityshäiriö

Mitenkähän mega-annosfoolihappoa  vaikuttaisi zikavirusvahinkoja vastaan?
https://jamanetwork.com/journals/jama/fullarticle/2593702

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Birth Defects Potentially Related to Zika Virus Infection During Pregnancy and Monitored by the US Zika Pregnancy Registry for Enhanced Surveillance

Brain Abnormalities With and Without Microcephaly

• Confirmed or possible congenital microcephaly^a
• Intracranial calcifications
• Cerebral atrophy
• Abnormal cortical formation (eg, polymicrogyria, lissencephaly, pachygyria, schizencephaly, gray matter heterotopia)
• Corpus callosum abnormalities
• Cerebellar abnormalities
• Porencephaly
• Hydranencephaly
• Ventriculomegaly/hydrocephaly (excluding “mild” ventriculomegaly without other brain abnormalities)
• Fetal brain disruption sequence (collapsed skull, overlapping sutures, prominent occipital bone, scalp rugae)
• Other major brain abnormalities including intraventricular hemorrhage in utero (excluding postnatal intraventricular hemorrhage)

Neural Tube Defects and Other Early Brain Malformations

• Neural tube defects including anencephaly, acrania, encephalocele, spina bifida
• Holoprosencephaly (arhinencephaly)

Eye Abnormalities

• Microphthalmia/anophthalmia
• Coloboma
• Cataract
• Intraocular calcifications
• Chorioretinal anomalies involving the macula (eg, chorioretinal atrophy and scarring, macular pallor, gross pigmentary mottling and retinal hemorrhage; excluding retinopathy of prematurity)
• Optic nerve atrophy, pallor, and other optic nerve abnormalities

Consequences of Central Nervous System Dysfunction

• Congenital contractures (eg, arthrogryposis, clubfoot, congenital hip dysplasia) with associated brain abnormalities
• Congenital deafness documented by postnatal audiological testing

^a Live births: measured head circumference (adjusted for gestational age and sex) less than the third percentile at birth or, if not measured at birth, within first 2 weeks of life. Pregnancy loss: prenatal head circumference more than 3 SDs below the mean based on ultrasound or postnatal head circumference less than the third percentile. Birth measurements are evaluated using the Intergrowth-21st standards (http://intergrowth21.ndog.ox.ac.uk/) based on measurements within 24 hours of birth.