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fredag 27 oktober 2017

Eroja pehmeiden ja kovien punkkien sialomix-rakenteessa


Muista silloij minua, kun punkki puree sinua.  (Vanha suomalainen sanonta) 
 Punkin puremaa EI tunne eikä  sitä huomaa, koska punkkisykki  on  niin puuduttavaa ainetta, mutta purematunne kestää kauan kuin skorpionin pisto eikä puremapaikan tuntoaistums katoa viikkoihin ehkä pitempikin aika kuluu ja  puremakohta tuntuu kutiavalta  ja pistävältä, aikka siitä olisi poistanut silmillänähtään punkkimateriaalin.  Punkin sylki ja puremajärjestelmä ovat tämän takia kiinostavia.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211429/
PMCID: PMC2211429
NIHMSID: NIHMS37009

Comparative sialomics between hard and soft ticks: Implications for the evolution of blood-feeding behavior

Author information ► Copyright and License information ►

Abstract

Ticks evolved various mechanisms to modulate their host’s hemostatic and immune defenses. Differences in the anti-hemostatic repertoires suggest that hard and soft ticks evolved anti-hemostatic mechanisms independently, but raise questions on the conservation of salivary gland proteins in the ancestral tick lineage. To address this issue the sialome (salivary gland secretory proteome) from the soft tick, Argas monolakensis was determined by proteomic analysis and cDNA library construction of salivary glands from fed and unfed adult female ticks. The sialome is composed of ~130 secretory proteins, of which the most abundant protein folds are the lipocalin, BTSP, BPTI and metalloprotease families which also comprise the most abundant proteins found in the salivary glands. Comparative analysis indicates that the major protein families are conserved in hard and soft ticks. Phylogenetic analysis shows, however, that most gene duplications are lineage specific, indicating that the protein families analyzed possibly evolved most of their functions after divergence of the two major tick families. In conclusion, the ancestral tick may have possessed a simple (few members for each family), but diverse (many different protein families) salivary gland protein domain repertoire.
Keywords: Argas, blood-feeding, evolution, proteome, sialome
 
Siirryn tästä metalloproteaasiblogiini MMP.

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