Crit Rev Microbiol. 2018 May;44(3):304-317. doi: 10.1080/1040841X.2017.1368999. Epub 2017 Sep 8.
Viral deubiquitinases: role in evasion of anti-viral innate immunity.
Host
anti-viral innate-immune signalling pathways are regulated by a variety
of post-translation modifications including ubiquitination, which is
critical to regulate various signalling pathways for synthesis of
anti-viral molecules. A homeostasis of host immune responses, induced
due to viral infection and further ubiquitination, is maintained by the
action of deubiquitinases (DUB). Infecting viruses
utilize the process of deubiquitination for tricking host immune system
wherein viral DUBs compete with host DUBs for inhibition of
innate-immune anti-viral signalling pathways, which instead of
maintaining an immune homeostasis bring about virus-mediated pathogenesis. This suggests that viruses co-evolve with their hosts to acquire similar machinery for tricking immune surveillance and establishing infection. KEYWORDS:
Viruses; anti-viral innate-immune signalling; host deubiquitinases; pattern recognition receptors; type I interferons; viral deubiquitinases PMID: 28885059 DOI: 10.1080/1040841X.2017.1368999
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