(2017) B-influenza virus triggeröinyt vauvalle MAS , makrofagien aktivaatiosyndroman

https://www.ncbi.nlm.nih.gov/pubmed/29279647

Indian J Crit Care Med. 2017 Nov;21(11):802-803. doi: 10.4103/0972-5229.218137.

Influenza B Virus Triggering Macrophage Activation Syndrome in an Infant.

Jayashree K¹, Rao S¹, Kamath N¹.

Abstract

Macrophage activation syndrome (MAS) is a potentially fatal complication caused by excessive activation and expansion of macrophages and T lymphocytes. It can be triggered by various infections and is characterized by the development of cytopenias, hyperferritinemia, liver dysfunction, and coagulopathy. We report a 10-month-old female infant with fever, convulsions, and hepatosplenomegaly. Laboratory data of bicytopenia, low erythrocyte sedimentation rate, and elevated liver enzymes suggested MAS. This was supported by the presence of hyperferritinemia with hypertriglyceridemia. MAS was triggered by influenza B virus. She responded to treatment with immunoglobulin and steroid.

KEYWORDS:

Bicytopenia; hyperferritinemia; hypertriglyceridemia; secondary hemophagocytic lymphohistiocytosis; thrombocytopenia

PMID:

29279647

PMCID:

PMC5699014

DOI:

10.4103/0972-5229.218137

Free PMC Article