LOCUS NC_012532 10794 bp RNA linear VRL 08-FEB-2016 DEFINITION Zika virus, complete genome. ACCESSION NC_012532 VERSION NC_012532.1 GI:226377833 DBLINK BioProject: PRJNA36615 KEYWORDS RefSeq. SOURCE Zika virus ORGANISM Zika virus Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage; Flaviviridae; Flavivirus. REFERENCE 1 (bases 1 to 10794) AUTHORS Kuno,G. and Chang,G.-J.J. TITLE Full-length sequencing and genomic characterization of Bagaza, Kedougou, and Zika viruses JOURNAL Arch Virol. 152 (4), 687-696 (2007) PUBMED 17195954 REFERENCE 2 (bases 1 to 10794) AUTHORS Kuno,G. and Chang,G.J. TITLE Biological transmission of arboviruses: reexamination of and new insights into components, mechanisms, and unique traits as well as their evolutionary trends JOURNAL Clin. Microbiol. Rev. 18 (4), 608-637 (2005) PUBMED 16223950 REFERENCE 3 (bases 1 to 10794) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (06-APR-2009) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 4 (bases 1 to 10794) AUTHORS Kuno,G. and Chang,G.-J.J. TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Division of Vector-Borne Infect. Dis., CDC, P.O. Box 2087, Fort Collins, CO 80522-2087, USA REMARK Sequence update by submitter REFERENCE 5 (bases 1 to 10794) AUTHORS Kuno,G., Chang,G.-J.J. and Tsuchiya,K.R. TITLE Direct Submission JOURNAL Submitted (21-MAY-2004) Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, P.O. Box 2087, Fort Collins, CO 80522, USA COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY632535. Mature peptides were annotated by RefSeq staff using the cleavage sites reported in Kuno and Chang, 2007 (PMID 17195954). Questions about the annotation of this sequence should be directed to info@ncbi.nlm.nih.gov. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..10794 /organism="Zika virus" /mol_type="genomic RNA" /strain="MR 766" /host="sentinel monkey" /db_xref="taxon:64320" /country="Uganda" /note="mosquito-borne flavivirus" 5'UTR 1..106 gene 107..10366 /gene="flavivirus polyprotein gene" /locus_tag="ZIKV_gp1" /db_xref="GeneID:7751225" CDS 107..10366 /gene="flavivirus polyprotein gene" /locus_tag="ZIKV_gp1" /codon_start=1 /product="flavivirus polyprotein" /protein_id="YP_002790881.1" /db_xref="GI:226377834" /db_xref="GeneID:7751225" /translation="MKNPKEEIRRIRIVNMLKRGVARVNPLGGLKRLPAGLLLGHGPI RMVLAILAFLRFTAIKPSLGLINRWGSVGKKEAMEIIKKFKKDLAAMLRIINARKERK RRGADTSIGIIGLLLTTAMAAEITRRGSAYYMYLDRSDAGKAISFATTLGVNKCHVQI MDLGHMCDATMSYECPMLDEGVEPDDVDCWCNTTSTWVVYGTCHHKKGEARRSRRAVT LPSHSTRKLQTRSQTWLESREYTKHLIKVENWIFRNPGFALVAVAIAWLLGSSTSQKV IYLVMILLIAPAYSIRCIGVSNRDFVEGMSGGTWVDVVLEHGGCVTVMAQDKPTVDIE LVTTTVSNMAEVRSYCYEASISDMASDSRCPTQGEAYLDKQSDTQYVCKRTLVDRGWG NGCGLFGKGSLVTCAKFTCSKKMTGKSIQPENLEYRIMLSVHGSQHSGMIGYETDEDR AKVEVTPNSPRAEATLGGFGSLGLDCEPRTGLDFSDLYYLTMNNKHWLVHKEWFHDIP LPWHAGADTGTPHWNNKEALVEFKDAHAKRQTVVVLGSQEGAVHTALAGALEAEMDGA KGRLFSGHLKCRLKMDKLRLKGVSYSLCTAAFTFTKVPAETLHGTVTVEVQYAGTDGP CKIPVQMAVDMQTLTPVGRLITANPVITESTENSKMMLELDPPFGDSYIVIGVGDKKI THHWHRSGSTIGKAFEATVRGAKRMAVLGDTAWDFGSVGGVFNSLGKGIHQIFGAAFK SLFGGMSWFSQILIGTLLVWLGLNTKNGSISLTCLALGGVMIFLSTAVSADVGCSVDF SKKETRCGTGVFIYNDVEAWRDRYKYHPDSPRRLAAAVKQAWEEGICGISSVSRMENI MWKSVEGELNAILEENGVQLTVVVGSVKNPMWRGPQRLPVPVNELPHGWKAWGKSYFV RAAKTNNSFVVDGDTLKECPLEHRAWNSFLVEDHGFGVFHTSVWLKVREDYSLECDPA VIGTAVKGREAAHSDLGYWIESEKNDTWRLKRAHLIEMKTCEWPKSHTLWTDGVEESD LIIPKSLAGPLSHHNTREGYRTQVKGPWHSEELEIRFEECPGTKVYVEETCGTRGPSL RSTTASGRVIEEWCCRECTMPPLSFRAKDGCWYGMEIRPRKEPESNLVRSMVTAGSTD HMDHFSLGVLVILLMVQEGLKKRMTTKIIMSTSMAVLVVMILGGFSMSDLAKLVILMG ATFAEMNTGGDVAHLALVAAFKVRPALLVSFIFRANWTPRESMLLALASCLLQTAISA LEGDLMVLINGFALAWLAIRAMAVPRTDNIALPILAALTPLARGTLLVAWRAGLATCG GIMLLSLKGKGSVKKNLPFVMALGLTAVRVVDPINVVGLLLLTRSGKRSWPPSEVLTA VGLICALAGGFAKADIEMAGPMAAVGLLIVSYVVSGKSVDMYIERAGDITWEKDAEVT GNSPRLDVALDESGDFSLVEEDGPPMREIILKVVLMAICGMNPIAIPFAAGAWYVYVK TGKRSGALWDVPAPKEVKKGETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTK GAALRSGEGRLDPYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERARNIQTL PGIFKTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAITQGKR EEETPVECFEPSMLKKKQLTVLDLHPGAGKTRRVLPEIVREAIKKRLRTVILAPTRVV AAEMEEALRGLPVRYMTTAVNVTHSGTEIVDLMCHATFTSRLLQPIRVPNYNLNIMDE AHFTDPSSIAARGYISTRVEMGEAAAIFMTATPPGTRDAFPDSNSPIMDTEVEVPERA WSSGFDWVTDHSGKTVWFVPSVRNGNEIAACLTKAGKRVIQLSRKTFETEFQKTKNQE WDFVITTDISEMGANFKADRVIDSRRCLKPVILDGERVILAGPMPVTHASAAQRRGRI GRNPNKPGDEYMYGGGCAETDEGHAHWLEARMLLDNIYLQDGLIASLYRPEADKVAAI EGEFKLRTEQRKTFVELMKRGDLPVWLAYQVASAGITYTDRRWCFDGTTNNTIMEDSV PAEVWTKYGEKRVLKPRWMDARVCSDHAALKSFKEFAAGKRGAALGVMEALGTLPGHM TERFQEAIDNLAVLMRAETGSRPYKAAAAQLPETLETIMLLGLLGTVSLGIFFVLMRN KGIGKMGFGMVTLGASAWLMWLSEIEPARIACVLIVVFLLLVVLIPEPEKQRSPQDNQ MAIIIMVAVGLLGLITANELGWLERTKNDIAHLMGRREEGATMGFSMDIDLRPASAWA IYAALTTLITPAVQHAVTTSYNNYSLMAMATQAGVLFGMGKGMPFMHGDLGVPLLMMG CYSQLTPLTLIVAIILLVAHYMYLIPGLQAAAARAAQKRTAAGIMKNPVVDGIVVTDI DTMTIDPQVEKKMGQVLLIAVAISSAVLLRTAWGWGEAGALITAATSTLWEGSPNKYW NSSTATSLCNIFRGSYLAGASLIYTVTRNAGLVKRRGGGTGETLGEKWKARLNQMSAL EFYSYKKSGITEVCREEARRALKDGVATGGHAVSRGSAKIRWLEERGYLQPYGKVVDL GCGRGGWSYYAATIRKVQEVRGYTKGGPGHEEPMLVQSYGWNIVRLKSGVDVFHMAAE PCDTLLCDIGESSSSPEVEETRTLRVLSMVGDWLEKRPGAFCIKVLCPYTSTMMETME RLQRRHGGGLVRVPLCRNSTHEMYWVSGAKSNIIKSVSTTSQLLLGRMDGPRRPVKYE EDVNLGSGTRAVASCAEAPNMKIIGRRIERIRNEHAETWFLDENHPYRTWAYHGSYEA PTQGSASSLVNGVVRLLSKPWDVVTGVTGIAMTDTTPYGQQRVFKEKVDTRVPDPQEG TRQVMNIVSSWLWKELGKRKRPRVCTKEEFINKVRSNAALGAIFEEEKEWKTAVEAVN DPRFWALVDREREHHLRGECHSCVYNMMGKREKKQGEFGKAKGSRAIWYMWLGARFLE FEALGFLNEDHWMGRENSGGGVEGLGLQRLGYILEEMNRAPGGKMYADDTAGWDTRIS KFDLENEALITNQMEEGHRTLALAVIKYTYQNKVVKVLRPAEGGKTVMDIISRQDQRG SGQVVTYALNTFTNLVVQLIRNMEAEEVLEMQDLWLLRKPEKVTRWLQSNGWDRLKRM AVSGDDCVVKPIDDRFAHALRFLNDMGKVRKDTQEWKPSTGWSNWEEVPFCSHHFNKL YLKDGRSIVVPCRHQDELIGRARVSPGAGWSIRETACLAKSYAQMWQLLYFHRRDLRL MANAICSAVPVDWVPTGRTTWSIHGKGEWMTTEDMLMVWNRVWIEENDHMEDKTPVTK WTDIPYLGKREDLWCGSLIGHRPRTTWAENIKDTVNMVRRIIGDEEKYMDYLSTQVRY LGEEGSTPGVL" mat_peptide 107..472 /gene="flavivirus polyprotein gene" /locus_tag="ZIKV_gp1" /product="anchored capsid protein C" /protein_id="YP_009227206.1" /db_xref="GI:985757037" mat_peptide 107..418 /gene="flavivirus polyprotein gene" /locus_tag="ZIKV_gp1" /product="capsid protein C" /protein_id="YP_009227196.1" /db_xref="GI:985757027" mat_peptide 473..976 /gene="flavivirus polyprotein gene" /locus_tag="ZIKV_gp1" /product="membrane glycoprotein precursor M" /protein_id="YP_009227197.1" /db_xref="GI:985757028" mat_peptide 473..751 /gene="flavivirus polyprotein gene" /locus_tag="ZIKV_gp1" /product="protein pr" /protein_id="YP_009227207.1" /db_xref="GI:985757038" mat_peptide 752..976 /gene="flavivirus polyprotein gene" /locus_tag="ZIKV_gp1" /product="membrane glycoprotein M" /protein_id="YP_009227208.1" /db_xref="GI:985757039" mat_peptide 977..2476 /gene="flavivirus polyprotein gene" /locus_tag="ZIKV_gp1" /product="envelope protein E" /protein_id="YP_009227198.1" /db_xref="GI:985757029" mat_peptide 2477..3532 /gene="flavivirus polyprotein gene" /locus_tag="ZIKV_gp1" /product="nonstructural protein NS1" /protein_id="YP_009227199.1" /db_xref="GI:985757030" mat_peptide 3533..4210 /gene="flavivirus polyprotein gene" /locus_tag="ZIKV_gp1" /product="nonstructural protein NS2A" /protein_id="YP_009227200.1" /db_xref="GI:985757031" mat_peptide 4211..4600 /gene="flavivirus polyprotein gene" /locus_tag="ZIKV_gp1" /product="nonstructural protein NS2B" /protein_id="YP_009227201.1" /db_xref="GI:985757032" mat_peptide 4601..6451 /gene="flavivirus polyprotein gene" /locus_tag="ZIKV_gp1" /product="nonstructural protein NS3" /protein_id="YP_009227202.1" /db_xref="GI:985757033" mat_peptide 6452..6832 /gene="flavivirus polyprotein gene" /locus_tag="ZIKV_gp1" /product="nonstructural protein NS4A" /protein_id="YP_009227203.1" /db_xref="GI:985757034" mat_peptide 6833..6901 /gene="flavivirus polyprotein gene" /locus_tag="ZIKV_gp1" /product="protein 2K" /protein_id="YP_009227209.1" /db_xref="GI:985757040" mat_peptide 6902..7654 /gene="flavivirus polyprotein gene" /locus_tag="ZIKV_gp1" /product="nonstructural protein NS4B" /protein_id="YP_009227204.1" /db_xref="GI:985757035" mat_peptide 7655..10363 /gene="flavivirus polyprotein gene" /locus_tag="ZIKV_gp1" /product="RNA-dependent RNA polymerase NS5" /protein_id="YP_009227205.1" /db_xref="GI:985757036" 3'UTR 10367..10794 ORIGIN 1 agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac 61 agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaaccccaa 121 agaagaaatc cggaggatcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtaaa 181 ccccttggga ggtttgaaga ggttgccagc cggacttctg ctgggtcatg gacccatcag 241 aatggttttg gcgatactag cctttttgag atttacagca atcaagccat cactgggcct 301 tatcaacaga tggggttccg tggggaaaaa agaggctatg gaaataataa agaagttcaa 361 gaaagatctt gctgccatgt tgagaataat caatgctagg aaagagagga agagacgtgg 421 cgcagacacc agcatcggaa tcattggcct cctgctgact acagccatgg cagcagagat 481 cactagacgc gggagtgcat actacatgta cttggatagg agcgatgccg ggaaggccat 541 ttcgtttgct accacattgg gagtgaacaa gtgccacgta cagatcatgg acctcgggca 601 catgtgtgac gccaccatga gttatgagtg ccctatgctg gatgagggag tggaaccaga 661 tgatgtcgat tgctggtgca acacgacatc aacttgggtt gtgtacggaa cctgtcatca 721 caaaaaaggt gaggcacggc gatctagaag agccgtgacg ctcccttctc actctacaag 781 gaagttgcaa acgcggtcgc agacctggtt agaatcaaga gaatacacga agcacttgat 841 caaggttgaa aactggatat tcaggaaccc cgggtttgcg ctagtggccg ttgccattgc 901 ctggcttttg ggaagctcga cgagccaaaa agtcatatac ttggtcatga tactgctgat 961 tgccccggca tacagtatca ggtgcattgg agtcagcaat agagacttcg tggagggcat 1021 gtcaggtggg acctgggttg atgttgtctt ggaacatgga ggctgcgtta ccgtgatggc 1081 acaggacaag ccaacagtcg acatagagtt ggtcacgacg acggttagta acatggccga 1141 ggtaagatcc tattgctacg aggcatcgat atcggacatg gcttcggaca gtcgttgccc 1201 aacacaaggt gaagcctacc ttgacaagca atcagacact caatatgtct gcaaaagaac 1261 attagtggac agaggttggg gaaacggttg tggacttttt ggcaaaggga gcttggtgac 1321 atgtgccaag tttacgtgtt ctaagaagat gaccgggaag agcattcaac cggaaaatct 1381 ggagtatcgg ataatgctat cagtgcatgg ctcccagcat agcgggatga ttggatatga 1441 aactgacgaa gatagagcga aagtcgaggt tacgcctaat tcaccaagag cggaagcaac 1501 cttgggaggc tttggaagct taggacttga ctgtgaacca aggacaggcc ttgacttttc 1561 agatctgtat tacctgacca tgaacaataa gcattggttg gtgcacaaag agtggtttca 1621 tgacatccca ttgccttggc atgctggggc agacaccgga actccacact ggaacaacaa 1681 agaggcattg gtagaattca aggatgccca cgccaagagg caaaccgtcg tcgttctggg 1741 gagccaggaa ggagccgttc acacggctct cgctggagct ctagaggctg agatggatgg 1801 tgcaaaggga aggctgttct ctggccattt gaaatgccgc ctaaaaatgg acaagcttag 1861 attgaagggc gtgtcatatt ccttgtgcac tgcggcattc acattcacca aggtcccagc 1921 tgaaacactg catggaacag tcacagtgga ggtgcagtat gcagggacag atggaccctg 1981 caagatccca gtccagatgg cggtggacat gcagaccctg accccagttg gaaggctgat 2041 aaccgccaac cccgtgatta ctgaaagcac tgagaactca aagatgatgt tggagcttga 2101 cccaccattt ggggattctt acattgtcat aggagttggg gacaagaaaa tcacccacca 2161 ctggcatagg agtggtagca ccatcggaaa ggcatttgag gccactgtga gaggcgccaa 2221 gagaatggca gtcctggggg atacagcctg ggacttcgga tcagtcgggg gtgtgttcaa 2281 ctcactgggt aagggcattc accagatttt tggagcagcc ttcaaatcac tgtttggagg 2341 aatgtcctgg ttctcacaga tcctcatagg cacgctgcta gtgtggttag gtttgaacac 2401 aaagaatgga tctatctccc tcacatgctt ggccctgggg ggagtgatga tcttcctctc 2461 cacggctgtt tctgctgacg tggggtgctc agtggacttc tcaaaaaagg aaacgagatg 2521 tggcacgggg gtattcatct ataatgatgt tgaagcctgg agggaccggt acaagtacca 2581 tcctgactcc ccccgcagat tggcagcagc agtcaagcag gcctgggaag aggggatctg 2641 tgggatctca tccgtttcaa gaatggaaaa catcatgtgg aaatcagtag aaggggagct 2701 caatgctatc ctagaggaga atggagttca actgacagtt gttgtgggat ctgtaaaaaa 2761 ccccatgtgg agaggtccac aaagattgcc agtgcctgtg aatgagctgc cccatggctg 2821 gaaagcctgg gggaaatcgt attttgttag ggcggcaaag accaacaaca gttttgttgt 2881 cgacggtgac acactgaagg aatgtccgct tgagcacaga gcatggaata gttttcttgt 2941 ggaggatcac gggtttggag tcttccacac cagtgtctgg cttaaggtca gagaagatta 3001 ctcattagaa tgtgacccag ccgtcatagg aacagctgtt aagggaaggg aggccgcgca 3061 cagtgatctg ggctattgga ttgaaagtga aaagaatgac acatggaggc tgaagagggc 3121 ccacctgatt gagatgaaaa catgtgaatg gccaaagtct cacacattgt ggacagatgg 3181 agtagaagaa agtgatctta tcatacccaa gtctttagct ggtccactca gccaccacaa 3241 caccagagag ggttacagaa cccaagtgaa agggccatgg cacagtgaag agcttgaaat 3301 ccggtttgag gaatgtccag gcaccaaggt ttacgtggag gagacatgcg gaactagagg 3361 accatctctg agatcaacta ctgcaagtgg aagggtcatt gaggaatggt gctgtaggga 3421 atgcacaatg cccccactat cgtttcgagc aaaagacggc tgctggtatg gaatggagat 3481 aaggcccagg aaagaaccag agagcaactt agtgaggtca atggtgacag cggggtcaac 3541 cgatcatatg gaccacttct ctcttggagt gcttgtgatt ctactcatgg tgcaggaggg 3601 gttgaagaag agaatgacca caaagatcat catgagcaca tcaatggcag tgctggtagt 3661 catgatcttg ggaggatttt caatgagtga cctggccaag cttgtgatcc tgatgggtgc 3721 tactttcgca gaaatgaaca ctggaggaga tgtagctcac ttggcattgg tagcggcatt 3781 taaagtcaga ccagccttgc tggtctcctt cattttcaga gccaattgga caccccgtga 3841 gagcatgctg ctagccctgg cttcgtgtct tctgcaaact gcgatctctg ctcttgaagg 3901 tgacttgatg gtcctcatta atggatttgc tttggcctgg ttggcaattc gagcaatggc 3961 cgtgccacgc actgacaaca tcgctctacc aatcttggct gctctaacac cactagctcg 4021 aggcacactg ctcgtggcat ggagagcggg cctggctact tgtggaggga tcatgctcct 4081 ctccctgaaa gggaaaggta gtgtgaagaa gaacctgcca tttgtcatgg ccctgggatt 4141 gacagctgtg agggtagtag accctattaa tgtggtagga ctactgttac tcacaaggag 4201 tgggaagcgg agctggcccc ctagtgaagt tctcacagcc gttggcctga tatgtgcact 4261 ggccggaggg tttgccaagg cagacattga gatggctgga cccatggctg cagtaggctt 4321 gctaattgtc agctatgtgg tctcgggaaa gagtgtggac atgtacattg aaagagcagg 4381 tgacatcaca tgggaaaagg acgcggaagt cactggaaac agtcctcggc ttgacgtggc 4441 actggatgag agtggtgact tctccttggt agaggaagat ggtccaccca tgagagagat 4501 catactcaag gtggtcctga tggccatctg tggcatgaac ccaatagcta taccttttgc 4561 tgcaggagcg tggtatgtgt atgtgaagac tgggaaaagg agtggcgccc tctgggacgt 4621 gcctgctccc aaagaagtga agaaaggaga gaccacagat ggagtgtaca gagtgatgac 4681 tcgcagactg ctaggttcaa cacaggttgg agtgggagtc atgcaagagg gagtcttcca 4741 caccatgtgg cacgttacaa aaggagccgc actgaggagc ggtgagggaa gacttgatcc 4801 atactggggg gatgtcaagc aggacttggt gtcatactgt gggccttgga agttggatgc 4861 agcttgggat ggactcagcg aggtacagct tttggccgta cctcccggag agagggccag 4921 aaacattcag accctgcctg gaatattcaa gacaaaggac ggggacatcg gagcagttgc 4981 tctggactac cctgcaggga cctcaggatc tccgatccta gacaaatgtg gaagagtgat 5041 aggactctat ggcaatgggg ttgtgatcaa gaatggaagc tatgttagtg ctataaccca 5101 gggaaagagg gaggaggaga ctccggttga atgtttcgaa ccctcgatgc tgaagaagaa 5161 gcagctaact gtcttggatc tgcatccagg agccggaaaa accaggagag ttcttcctga 5221 aatagtccgt gaagccataa aaaagagact ccggacagtg atcttggcac caactagggt 5281 tgtcgctgct gagatggagg aggccttgag aggacttccg gtgcgttaca tgacaacagc 5341 agtcaacgtc acccattctg ggacagaaat cgttgatttg atgtgccatg ccactttcac 5401 ttcacgctta ctacaaccca tcagagtccc taattacaat ctcaacatca tggatgaagc 5461 ccacttcaca gacccctcaa gtatagctgc aagaggatac atatcaacaa gggttgaaat 5521 gggcgaggcg gctgccattt ttatgactgc cacaccacca ggaacccgtg atgcgtttcc 5581 tgactctaac tcaccaatca tggacacaga agtggaagtc ccagagagag cctggagctc 5641 aggctttgat tgggtgacag accattctgg gaaaacagtt tggttcgttc caagcgtgag 5701 aaacggaaat gaaatcgcag cctgtctgac aaaggctgga aagcgggtca tacagctcag 5761 caggaagact tttgagacag aatttcagaa aacaaaaaat caagagtggg actttgtcat 5821 aacaactgac atctcagaga tgggcgccaa cttcaaggct gaccgggtca tagactctag 5881 gagatgccta aaaccagtca tacttgatgg tgagagagtc atcttggctg ggcccatgcc 5941 tgtcacgcat gctagtgctg ctcagaggag aggacgtata ggcaggaacc ctaacaaacc 6001 tggagatgag tacatgtatg gaggtgggtg tgcagagact gatgaaggcc atgcacactg 6061 gcttgaagca agaatgcttc ttgacaacat ctacctccag gatggcctca tagcctcgct 6121 ctatcggcct gaggccgata aggtagccgc cattgaggga gagtttaagc tgaggacaga 6181 gcaaaggaag accttcgtgg aactcatgaa gagaggagac cttcccgtct ggctagccta 6241 tcaggttgca tctgccggaa taacttacac agacagaaga tggtgctttg atggcacaac 6301 caacaacacc ataatggaag acagtgtacc agcagaggtt tggacaaagt atggagagaa 6361 gagagtgctc aaaccgagat ggatggatgc tagggtctgt tcagaccatg cggccctgaa 6421 gtcgttcaaa gaattcgccg ctggaaaaag aggagcggct ttgggagtaa tggaggccct 6481 gggaacactg ccaggacaca tgacagagag gtttcaggaa gccattgaca acctcgccgt 6541 gctcatgcga gcagagactg gaagcaggcc ttataaggca gcggcagccc aactgccgga 6601 gaccctagag accattatgc tcttaggttt gctgggaaca gtttcactgg ggatcttctt 6661 cgtcttgatg cggaataagg gcatcgggaa gatgggcttt ggaatggtaa cccttggggc 6721 cagtgcatgg ctcatgtggc tttcggaaat tgaaccagcc agaattgcat gtgtcctcat 6781 tgttgtgttt ttattactgg tggtgctcat acccgagcca gagaagcaaa gatctcccca 6841 agataaccag atggcaatta tcatcatggt ggcagtgggc cttctaggtt tgataactgc 6901 aaacgaactt ggatggctgg aaagaacaaa aaatgacata gctcatctaa tgggaaggag 6961 agaagaagga gcaaccatgg gattctcaat ggacattgat ctgcggccag cctccgcctg 7021 ggctatctat gccgcattga caactctcat caccccagct gtccaacatg cggtaaccac 7081 ttcatacaac aactactcct taatggcgat ggccacacaa gctggagtgc tgtttggcat 7141 gggcaaaggg atgccattta tgcatgggga ccttggagtc ccgctgctaa tgatgggttg 7201 ctattcacaa ttaacacccc tgactctgat agtagctatc attctgcttg tggcgcacta 7261 catgtacttg atcccaggcc tacaagcggc agcagcgcgt gctgcccaga aaaggacagc 7321 agctggcatc atgaagaatc ccgttgtgga tggaatagtg gtaactgaca ttgacacaat 7381 gacaatagac ccccaggtgg agaagaagat gggacaagtg ttactcatag cagtagccat 7441 ctccagtgct gtgctgctgc ggaccgcctg gggatggggg gaggctggag ctctgatcac 7501 agcagcgacc tccaccttgt gggaaggctc tccaaacaaa tactggaact cctctacagc 7561 cacctcactg tgcaacatct tcagaggaag ctatctggca ggagcttccc ttatctatac 7621 agtgacgaga aacgctggcc tggttaagag acgtggaggt gggacgggag agactctggg 7681 agagaagtgg aaagctcgtc tgaatcagat gtcggccctg gagttctact cttataaaaa 7741 gtcaggtatc actgaagtgt gtagagagga ggctcgccgt gccctcaagg atggagtggc 7801 cacaggagga catgccgtat cccggggaag tgcaaagatc agatggttgg aggagagagg 7861 atatctgcag ccctatggga aggttgttga cctcggatgt ggcagagggg gctggagcta 7921 ttatgccgcc accatccgca aagtgcagga ggtgagagga tacacaaagg gaggtcccgg 7981 tcatgaagaa cccatgctgg tgcaaagcta tgggtggaac atagttcgtc tcaagagtgg 8041 agtggacgtc ttccacatgg cggctgagcc gtgtgacact ctgctgtgtg acataggtga 8101 gtcatcatct agtcctgaag tggaagagac acgaacactc agagtgctct ctatggtggg 8161 ggactggctt gaaaaaagac caggggcctt ctgtataaag gtgctgtgcc catacaccag 8221 cactatgatg gaaaccatgg agcgactgca acgtaggcat gggggaggat tagtcagagt 8281 gccattgtgt cgcaactcca cacatgagat gtactgggtc tctggggcaa agagcaacat 8341 cataaaaagt gtgtccacca caagtcagct cctcctggga cgcatggatg gccccaggag 8401 gccagtgaaa tatgaggagg atgtgaacct cggctcgggt acacgagctg tggcaagctg 8461 tgctgaggct cctaacatga aaatcatcgg caggcgcatt gagagaatcc gcaatgaaca 8521 tgcagaaaca tggtttcttg atgaaaacca cccatacagg acatgggcct accatgggag 8581 ctacgaagcc cccacgcaag gatcagcgtc ttccctcgtg aacggggttg ttagactcct 8641 gtcaaagcct tgggacgtgg tgactggagt tacaggaata gccatgactg acaccacacc 8701 atacggccaa caaagagtct tcaaagaaaa agtggacacc agggtgccag atccccaaga 8761 aggcactcgc caggtaatga acatagtctc ttcctggctg tggaaggagc tggggaaacg 8821 caagcggcca cgcgtctgca ccaaagaaga gtttatcaac aaggtgcgca gcaatgcagc 8881 actgggagca atatttgaag aggaaaaaga atggaagacg gctgtggaag ctgtgaatga 8941 tccaaggttt tgggccctag tggataggga gagagaacac cacctgagag gagagtgtca 9001 cagctgtgtg tacaacatga tgggaaaaag agaaaagaag caaggagagt tcgggaaagc 9061 aaaaggtagc cgcgccatct ggtacatgtg gttgggagcc agattcttgg agtttgaagc 9121 ccttggattc ttgaacgagg accattggat gggaagagaa aactcaggag gtggagtcga 9181 agggttagga ttgcaaagac ttggatacat tctagaagaa atgaatcggg caccaggagg 9241 aaagatgtac gcagatgaca ctgctggctg ggacacccgc attagtaagt ttgatctgga 9301 gaatgaagct ctgattacca accaaatgga ggaagggcac agaactctgg cgttggccgt 9361 gattaaatac acataccaaa acaaagtggt gaaggttctc agaccagctg aaggaggaaa 9421 aacagttatg gacatcattt caagacaaga ccagagaggg agtggacaag ttgtcactta 9481 tgctctcaac acattcacca acttggtggt gcagcttatc cggaacatgg aagctgagga 9541 agtgttagag atgcaagact tatggttgtt gaggaagcca gagaaagtga ccagatggtt 9601 gcagagcaat ggatgggata gactcaaacg aatggcggtc agtggagatg actgcgttgt 9661 gaagccaatc gatgataggt ttgcacatgc cctcaggttc ttgaatgaca tgggaaaagt 9721 taggaaagac acacaggagt ggaaaccctc gactggatgg agcaattggg aagaagtccc 9781 gttctgctcc caccacttca acaagctgta cctcaaggat gggagatcca ttgtggtccc 9841 ttgccgccac caagatgaac tgattggccg agctcgcgtc tcaccagggg caggatggag 9901 catccgggag actgcctgtc ttgcaaaatc atatgcgcag atgtggcagc tcctttattt 9961 ccacagaaga gaccttcgac tgatggctaa tgccatttgc tcggctgtgc cagttgactg 10021 ggtaccaact gggagaacca cctggtcaat ccatggaaag ggagaatgga tgaccactga 10081 ggacatgctc atggtgtgga atagagtgtg gattgaggag aacgaccata tggaggacaa 10141 gactcctgta acaaaatgga cagacattcc ctatctagga aaaagggagg acttatggtg 10201 tggatccctt atagggcaca gaccccgcac cacttgggct gaaaacatca aagacacagt 10261 caacatggtg cgcaggatca taggtgatga agaaaagtac atggactatc tatccaccca 10321 agtccgctac ttgggtgagg aagggtccac acccggagtg ttgtaagcac caattttagt 10381 gttgtcaggc ctgctagtca gccacagttt ggggaaagct gtgcagcctg taaccccccc 10441 aggagaagct gggaaaccaa gctcatagtc aggccgagaa cgccatggca cggaagaagc 10501 catgctgcct gtgagcccct cagaggacac tgagtcaaaa aaccccacgc gcttggaagc 10561 gcaggatggg aaaagaaggt ggcgaccttc cccacccttc aatctggggc ctgaactgga 10621 gactagctgt gaatctccag cagagggact agtggttaga ggagaccccc cggaaaacgc 10681 aaaacagcat attgacgtgg gaaagaccag agactccatg agtttccacc acgctggccg 10741 ccaggcacag atcgccgaac ttcggcggcc ggtgtgggga aatccatggt ttct
söndag 21 augusti 2016
Zikavirusgenomi (sitaatti)
Tämä on pitkä sitaatti PubMed Genomi Zika viruksesta, mutta on syytä ottaa insiktin herättämisen takia esiin.
ZIKA-virus genomeja selvitetty ainakin kolme toisistaan eriävää kantaa
Genome Announc. 2016 Aug 18;4(4). pii: e00800-16. doi: 10.1128/genomeA.00800-16.
Complete Genome Sequences of Three Historically Important, Spatiotemporally Distinct, and Genetically Divergent Strains of Zika Virus: MR-766, P6-740, and PRVABC-59.
Yun SI1, Song BH1, Frank JC1, Julander JG1, Polejaeva IA1, Davies CJ1, White KL1, Lee YM2
MR-766 (African lineage, Uganda, 1947),
P6-740 (Asian lineage, Malaysia, 1966),
and PRVABC-59 (Asian lineage-derived American strain, Puerto Rico, 2015).
Abstract
Here, we report the 10,807-nucleotide-long consensus RNA genome sequences of three spatiotemporally distinct and genetically divergent Zika virus strains, with the functionality of their genomic sequences substantiated by reverse geneticsMR-766 (African lineage, Uganda, 1947),
P6-740 (Asian lineage, Malaysia, 1966),
and PRVABC-59 (Asian lineage-derived American strain, Puerto Rico, 2015).
fredag 19 augusti 2016
Zikavirus voittaa alueita
Zikavirusta voi käytännöllisesti katsoen pitää hyvin varhaisen dementian aiheuttavana viruksena mikrokefalian takia. Tämä kongenitaalidementia on kehitysvammaisuus retardatio mentalis profunda.
Irakissa runsasta siipikarjakuolemaa AIV virukseen
http://www.thepoultrysite.com/poultrynews/37376/iraqs-avian-flu-outbreaks-killing-millions-of-birds/
IRAQ - Outbreaks of a H5 strain of highly pathogenic avian influenza virus spread on farms in central Iraq in June and July.
Eleven outbreaks were reported in total, mainly affecting Baghdad but also the nearby Wasit region.
In total, 2.8 million birds died or were destroyed in the outbreaks. The source of the outbreaks is unknown.
As well as stamping out and disinfection, the country is using movement controls and surveillance measures to prevent further spread.
Sodan, nälänhädän, kuivuuden, pakolaisvirtojen lisäksi siipikarjan suurimitainen kuolema on paha isku väestölle. Saati sitten se vaara, että uusi pandemiavirus lähtee vähitellen ihmiskunnan puolelle tuosta kurjuuden myräkästä.
IRAQ - Outbreaks of a H5 strain of highly pathogenic avian influenza virus spread on farms in central Iraq in June and July.
Eleven outbreaks were reported in total, mainly affecting Baghdad but also the nearby Wasit region.
In total, 2.8 million birds died or were destroyed in the outbreaks. The source of the outbreaks is unknown.
As well as stamping out and disinfection, the country is using movement controls and surveillance measures to prevent further spread.
Sodan, nälänhädän, kuivuuden, pakolaisvirtojen lisäksi siipikarjan suurimitainen kuolema on paha isku väestölle. Saati sitten se vaara, että uusi pandemiavirus lähtee vähitellen ihmiskunnan puolelle tuosta kurjuuden myräkästä.
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