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fredag 5 juli 2019

Deubikitinaasit virusinfektiossa, hDUB ja vDUB

https://www.ncbi.nlm.nih.gov/pubmed/28885059

2018 May;44(3):304-317. doi: 10.1080/1040841X.2017.1368999. Epub 2017 Sep 8.
Viral deubiquitinases: role in evasion of anti-viral innate immunity.
Kumari P1, Kumar H1. Abstract
Host anti-viral innate-immune signalling pathways are regulated by a variety of post-translation modifications including ubiquitination, which is critical to regulate various signalling pathways for synthesis of anti-viral molecules. A homeostasis of host immune responses, induced due to viral infection and further ubiquitination, is maintained by the action of deubiquitinases (DUB). Infecting viruses utilize the process of deubiquitination for tricking host immune system wherein viral DUBs compete with host DUBs for inhibition of innate-immune anti-viral signalling pathways, which instead of maintaining an immune homeostasis bring about virus-mediated pathogenesis. This suggests that viruses co-evolve with their hosts to acquire similar machinery for tricking immune surveillance and establishing infection. KEYWORDS:
Viruses; anti-viral innate-immune signalling; host deubiquitinases; pattern recognition receptors; type I interferons; viral deubiquitinases PMID: 28885059 DOI: 10.1080/1040841X.2017.1368999

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