Rabies leviää Libanonissa pakolaisleiriolosuhteiden jatkuessa

Muistiin 24.2.2018

http://www.dailystar.com.lb/News/Lebanon-News/2018/Feb-24/439191-hasbani-links-rabies-spike-to-refugee-influx.ashx

Concerning Travellers to Lebanon:

Rabies can be found in dogs, bats, and other mammals in Lebanon, so CDC recommends this vaccine for the following groups:

• Travelers involved in outdoor and other activities (such as camping, hiking, biking, adventure travel, and caving) that put them at risk for animal bites.
• People who will be working with or around animals (such as veterinarians, wildlife professionals, and researchers).
• People who are taking long trips or moving to Lebanon
• Children, because they tend to play with animals, might not report bites, and are more likely to have animal bites on their head and neck.
  

Ps. 89:15,16

6.2.2018,10:12.Sana psalmista 86:15,16.

(A Maskil of Ethan the Ezrahite) Blessed are the people who know the festal shout, who walk , o Lord, in the light of thy countenance.who exult in thy name all the day, and extol thy righteousness.

Uutta Pathogeeneista. otsikoita 2.2. 2018

 http://journals.plos.org/plospathogens/issue

Opinions

The curious case of APOBEC3 activation by cancer-associated human papillomaviruses

Nicholas A. Wallace, Karl Münger

PLOS Pathogens: published January 11, 2018 | https://doi.org/10.1371/journal.ppat.1006717

Although it's painful: The importance of stringent antibody validation

Victoria A. Meliopoulos, Stacey Schultz-Cherry

PLOS Pathogens: published January 4, 2018 | https://doi.org/10.1371/journal.ppat.1006701

Pearls

Does nonreproductive swarming adapt to pathogens?

Qingyun Diao, Chunsheng Hou

PLOS Pathogens: published January 25, 2018 | https://doi.org/10.1371/journal.ppat.1006742

The oral microbiome: A Lesson in coexistence

Ahmed S. Sultan, Eric F. Kong, Alexandra M. Rizk, Mary Ann Jabra-Rizk

PLOS Pathogens: published January 25, 2018 | https://doi.org/10.1371/journal.ppat.1006719

Habits of a highly successful cereal killer, Striga

Steven Runo, Eric K. Kuria

PLOS Pathogens: published January 11, 2018 | https://doi.org/10.1371/journal.ppat.1006731

Chaperone functional specificity promotes yeast prion diversity

Andrea N. Killian, Justin K. Hines

PLOS Pathogens: published January 4, 2018 | https://doi.org/10.1371/journal.ppat.1006695

From phagocytosis to metaforosis: Calcineurin’s deadly role in innate processing of fungi

Darius Armstrong-James, Leon de Boer, Amelia Bercusson, Anand Shah

PLOS Pathogens: published January 4, 2018 | https://doi.org/10.1371/journal.ppat.1006627

Review

Tissue-specific transcriptome analyses provide new insights into GPCR signalling in adult Schistosoma mansoni

Steffen Hahnel, Nic Wheeler, Zhigang Lu, Arporn Wangwiwatsin, Paul McVeigh, Aaron Maule, Matthew Berriman, Timothy Day, Paula Ribeiro, Christoph G. Grevelding

PLOS Pathogens: published January 18, 2018 | https://doi.org/10.1371/journal.ppat.1006718

Research Articles

The fungal pathogen Magnaporthe oryzae suppresses innate immunity by modulating a host potassium channel

Xuetao Shi, Yu Long, Feng He, Chongyang Zhang, Ruyi Wang, Ting Zhang, Wei Wu, Zeyun Hao, Yi Wang, Guo-Liang Wang, Yuese Ning

PLOS Pathogens: published January 31, 2018 | https://doi.org/10.1371/journal.ppat.1006878

Recombinant PrP^Sc shares structural features with brain-derived PrP^Sc: Insights from limited proteolysis

Alejandro M. Sevillano, Natalia Fernández-Borges, Neelam Younas, Fei Wang, Saioa R. Elezgarai, Susana Bravo, Ester Vázquez-Fernández, Isaac Rosa, Hasier Eraña, David Gil, Sonia Veiga, Enric Vidal, Melissa L. Erickson-Beltran, Esteban Guitián, Christopher J. Silva, Romolo Nonno, Jiyan Ma, Joaquín Castilla, Jesús R. Requena

PLOS Pathogens: published January 31, 2018 | https://doi.org/10.1371/journal.ppat.1006797

A new mechanism of interferon’s antiviral action: Induction of autophagy, essential for paramyxovirus replication, is inhibited by the interferon stimulated gene, TDRD7

Gayatri Subramanian, Teodora Kuzmanovic, Ying Zhang, Cara Beate Peter, Manoj Veleeparambil, Ritu Chakravarti, Ganes C. Sen, Saurabh Chattopadhyay

PLOS Pathogens: published January 30, 2018 | https://doi.org/10.1371/journal.ppat.1006877

The Xanthomonas euvesicatoria type III effector XopAU is an active protein kinase that manipulates plant MAP kinase signaling

Doron Teper, Anil Madhusoodana Girija, Eran Bosis, Georgy Popov, Alon Savidor, Guido Sessa

PLOS Pathogens: published January 29, 2018 | https://doi.org/10.1371/journal.ppat.1006880

Human cytomegalovirus UL23 inhibits transcription of interferon-γ stimulated genes and blocks antiviral interferon-γ responses by interacting with human N-myc interactor protein

Linyuan Feng, Jingxue Sheng, Gia-Phong Vu, Yujun Liu, Chingman Foo, Songbin Wu, Phong Trang, Marco Paliza-Carre, Yanhong Ran, Xiaoping Yang, Xu Sun, Zemin Deng, Tianhong Zhou, Sangwei Lu, Hongjian Li, Fenyong Liu

PLOS Pathogens: published January 29, 2018 | https://doi.org/10.1371/journal.ppat.1006867

Attenuation of a very virulent Marek's disease herpesvirus (MDV) by codon pair bias deoptimization

Kathrin Eschke, Jakob Trimpert, Nikolaus Osterrieder, Dusan Kunec

PLOS Pathogens: published January 29, 2018 | https://doi.org/10.1371/journal.ppat.1006857

Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes

Michela Mazzon, Cecilia Castro, Bastian Thaa, Lifeng Liu, Margit Mutso, Xiang Liu, Suresh Mahalingam, Julian L. Griffin, Mark Marsh, Gerald M. McInerney

PLOS Pathogens: published January 29, 2018 | https://doi.org/10.1371/journal.ppat.1006835

Global synonymous mutagenesis identifies cis-acting RNA elements that regulate HIV-1 splicing and replication

Matthew Takata, Steven J. Soll, Ann Emery, Daniel Blanco-Melo, Ronald Swanstrom, Paul D. Bieniasz

PLOS Pathogens: published January 29, 2018 | https://doi.org/10.1371/journal.ppat.1006824

Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-γ/HIF-1α signaling and supports host defense

Matthew Knight, Jonathan Braverman, Kaleb Asfaha, Karsten Gronert, Sarah Stanley

PLOS Pathogens: published January 25, 2018 | https://doi.org/10.1371/journal.ppat.1006874

Intracellular trafficking of begomoviruses in the midgut cells of their insect vector

Wen-Qiang Xia, Yan Liang, Yao Chi, Li-Long Pan, Jing Zhao, Shu-Sheng Liu, Xiao-Wei Wang

PLOS Pathogens: published January 25, 2018 | https://doi.org/10.1371/journal.ppat.1006866

Two closely related Rho GTPases, Cdc42 and RacA, of the en-dophytic fungus Epichloë festucae have contrasting roles for ROS production and symbiotic infection synchronized with the host plant

Yuka Kayano, Aiko Tanaka, Daigo Takemoto

PLOS Pathogens: published January 25, 2018 | https://doi.org/10.1371/journal.ppat.1006840

MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infection

Javier Canton, Anthony R. Fehr, Raúl Fernandez-Delgado, Francisco J. Gutierrez-Alvarez, Maria T. Sanchez-Aparicio, Adolfo García-Sastre, Stanley Perlman, Luis Enjuanes, Isabel Sola

PLOS Pathogens: published January 25, 2018 | https://doi.org/10.1371/journal.ppat.1006838

Phenotypic deficits in the HIV-1 envelope are associated with the maturation of a V2-directed broadly neutralizing antibody lineage

Lucia Reh, Carsten Magnus, Claus Kadelka, Denise Kühnert, Therese Uhr, Jacqueline Weber, Lynn Morris, Penny L. Moore, Alexandra Trkola

PLOS Pathogens: published January 25, 2018 | https://doi.org/10.1371/journal.ppat.1006825

The Wolbachia strain wAu provides highly efficient virus transmission blocking in Aedes aegypti

Thomas H. Ant, Christie S. Herd, Vincent Geoghegan, Ary A. Hoffmann, Steven P. Sinkins

PLOS Pathogens: published January 25, 2018 | https://doi.org/10.1371/journal.ppat.1006815

Alterations of HIV-1 envelope phenotype and antibody-mediated neutralization by signal peptide mutations

Chitra Upadhyay, Roya Feyznezhad, Weiming Yang, Hui Zhang, Susan Zolla-Pazner, Catarina E. Hioe

PLOS Pathogens: published January 25, 2018 | https://doi.org/10.1371/journal.ppat.1006812

Conditional mutagenesis in vivo reveals cell type- and infection stage-specific requirements for LANA in chronic MHV68 infection

Eduardo Salinas, Arundhati Gupta, Jeffrey M. Sifford, Darby G. Oldenburg, Douglas W. White, J. Craig Forrest

PLOS Pathogens: published January 24, 2018 | https://doi.org/10.1371/journal.ppat.1006865

The structure of FIV reverse transcriptase and its implications for non-nucleoside inhibitor resistance

Meytal Galilee, Akram Alian

PLOS Pathogens: published January 24, 2018 | https://doi.org/10.1371/journal.ppat.1006849

Cathepsin B aggravates coxsackievirus B3-induced myocarditis through activating the inflammasome and promoting pyroptosis

Yaping Wang, Liangliang Jia, Jian Shen, Yidong Wang, Zurong Fu, Sheng-an Su, Zhejun Cai, Jian-an Wang, Meixiang Xiang

PLOS Pathogens: published January 23, 2018 | https://doi.org/10.1371/journal.ppat.1006872

Interferon regulatory factor 8 regulates caspase-1 expression to facilitate Epstein-Barr virus reactivation in response to B cell receptor stimulation and chemical induction

Dong-Wen Lv, Kun Zhang, Renfeng Li

PLOS Pathogens: published January 22, 2018 | https://doi.org/10.1371/journal.ppat.1006868

Infectious blood source alters early foregut infection and regurgitative transmission of Yersinia pestis by rodent fleas

David M. Bland, Clayton O. Jarrett, Christopher F. Bosio, B. Joseph Hinnebusch

PLOS Pathogens: published January 22, 2018 | https://doi.org/10.1371/journal.ppat.1006859

Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome

Soham Gupta, Päivi Ylä-Anttila, Simone Callegari, Ming-Han Tsai, Henri-Jacques Delecluse, Maria G. Masucci

PLOS Pathogens: published January 22, 2018 | https://doi.org/10.1371/journal.ppat.1006852

Identification of a novel protein complex essential for effector translocation across the parasitophorous vacuole membrane of Toxoplasma gondii

Nicole D. Marino, Michael W. Panas, Magdalena Franco, Terence C. Theisen, Adit Naor, Suchita Rastogi, Kerry R. Buchholz, Hernan A. Lorenzi, John C. Boothroyd

PLOS Pathogens: published January 22, 2018 | https://doi.org/10.1371/journal.ppat.1006828

The fungal myosin I is essential for Fusarium toxisome formation

Guangfei Tang, Yun Chen, Jin-Rong Xu, H. Corby Kistler, Zhonghua Ma

PLOS Pathogens: published January 22, 2018 | https://doi.org/10.1371/journal.ppat.1006827

Regional and subtype-dependent miRNA signatures in sporadic Creutzfeldt-Jakob disease are accompanied by alterations in miRNA silencing machinery and biogenesis

Franc Llorens, Katrin Thüne, Eulàlia Martí, Eirini Kanata, Dimitra Dafou, Daniela Díaz-Lucena, Ana Vivancos, Orr Shomroni, Saima Zafar, Matthias Schmitz, Uwe Michel, Natalia Fernández-Borges, Olivier Andréoletti, José Antonio del Río, Juana Díez, Andre Fischer, Stefan Bonn, Theodoros Sklaviadis, Juan Maria Torres, Isidre Ferrer, Inga Zerr

PLOS Pathogens: published January 22, 2018 | https://doi.org/10.1371/journal.ppat.1006802

Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication

Weiyu Luo, Jie Zhang, Libin Liang, Guangwen Wang, Qibing Li, Pengyang Zhu, Yuan Zhou, Junping Li, Yuhui Zhao, Nan Sun, Shanyu Huang, Chenchen Zhou, Yu Chang, Pengfei Cui, Pucheng Chen, Yongping Jiang, Guohua Deng, Zhigao Bu, Chengjun Li, Li Jiang, Hualan Chen

PLOS Pathogens: published January 19, 2018 | https://doi.org/10.1371/journal.ppat.1006851

Bunyavirus requirement for endosomal K⁺ reveals new roles of cellular ion channels during infection

Samantha Hover, Becky Foster, Juan Fontana, Alain Kohl, Steve A. N. Goldstein, John N. Barr, Jamel Mankouri

PLOS Pathogens: published January 19, 2018 | https://doi.org/10.1371/journal.ppat.1006845

RNA-Seq of Kaposi’s sarcoma reveals alterations in glucose and lipid metabolism

For Yue Tso, Andrew V. Kossenkov, Salum J. Lidenge, Owen Ngalamika, John R. Ngowi, Julius Mwaiselage, Jayamanna Wickramasinghe, Eun Hee Kwon, John T. West, Paul M. Lieberman, Charles Wood

PLOS Pathogens: published January 19, 2018 | https://doi.org/10.1371/journal.ppat.1006844

A role for domain I of the hepatitis C virus NS5A protein in virus assembly

Chunhong Yin, Niluka Goonawardane, Hazel Stewart, Mark Harris

PLOS Pathogens: published January 19, 2018 | https://doi.org/10.1371/journal.ppat.1006834

IFNγ inhibits G-CSF induced neutrophil expansion and invasion of the CNS to prevent viral encephalitis

Chandran Ramakrishna, Edouard M. Cantin

PLOS Pathogens: published January 19, 2018 | https://doi.org/10.1371/journal.ppat.1006822

Activation of PI3K, Akt, and ERK during early rotavirus infection leads to V-ATPase-dependent endosomal acidification required for uncoating

Mahmoud Soliman, Ja-Young Seo, Deok-Song Kim, Ji-Yun Kim, Jun-Gyu Park, Mia Madel Alfajaro, Yeong-Bin Baek, Eun-Hyo Cho, Joseph Kwon, Jong-Soon Choi, Mun-Il Kang, Sang-Ik Park, Kyoung-Oh Cho

PLOS Pathogens: published January 19, 2018 | https://doi.org/10.1371/journal.ppat.1006820

Leishmania proteophosphoglycans regurgitated from infected sand flies accelerate dermal wound repair and exacerbate leishmaniasis via insulin-like growth factor 1-dependent signalling

Emilie Giraud, Tereza Lestinova, Tamsyn Derrick, Oihane Martin, Rod J. Dillon, Petr Volf, Ingrid Műller, Paul A. Bates, Matthew E. Rogers

PLOS Pathogens: published January 19, 2018 | https://doi.org/10.1371/journal.ppat.1006794

Decoding the network of Trypanosoma brucei proteins that determines sensitivity to apolipoprotein-L1

Rachel B. Currier, Anneli Cooper, Hollie Burrell-Saward, Annette MacLeod, Sam Alsford

PLOS Pathogens: published January 18, 2018 | https://doi.org/10.1371/journal.ppat.1006855

Initial acquisition and succession of the cystic fibrosis lung microbiome is associated with disease progression in infants and preschool children

Marianne S. Muhlebach, Bryan T. Zorn, Charles R. Esther, Joseph E. Hatch, Conor P. Murray, Lidija Turkovic, Sarath C. Ranganathan, Richard C. Boucher, Stephen M. Stick, Matthew C. Wolfgang

PLOS Pathogens: published January 18, 2018 | https://doi.org/10.1371/journal.ppat.1006798

Influenza A virus hemagglutinin glycosylation compensates for antibody escape fitness costs

Ivan Kosik, William L. Ince, Lauren E. Gentles, Andrew J. Oler, Martina Kosikova, Matthew Angel, Javier G. Magadán, Hang Xie, Christopher B. Brooke, Jonathan W. Yewdell

PLOS Pathogens: published January 18, 2018 | https://doi.org/10.1371/journal.ppat.1006796

Xylose donor transport is critical for fungal virulence

Lucy X. Li, Carsten Rautengarten, Joshua L. Heazlewood, Tamara L. Doering

PLOS Pathogens: published January 18, 2018 | https://doi.org/10.1371/journal.ppat.1006765

Higher sequence diversity in the vaginal tract than in blood at early HIV-1 infection

Katja Klein, Gabrielle Nickel, Immaculate Nankya, Fred Kyeyune, Korey Demers, Emmanuel Ndashimye, Cynthia Kwok, Pai-Lien Chen, Sandra Rwambuya, Art Poon, Marshall Munjoma, Tsungai Chipato, Josaphat Byamugisha, Peter Mugyenyi, Robert A. Salata, Charles S. Morrison, Eric J. Arts

PLOS Pathogens: published January 18, 2018 | https://doi.org/10.1371/journal.ppat.1006754

Ebola virus requires a host scramblase for externalization of phosphatidylserine on the surface of viral particles

Asuka Nanbo, Junki Maruyama, Masaki Imai, Michiko Ujie, Yoichiro Fujioka, Shinya Nishide, Ayato Takada, Yusuke Ohba, Yoshihiro Kawaoka

PLOS Pathogens: published January 16, 2018 | https://doi.org/10.1371/journal.ppat.1006848

A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles

Robert C. C. Mercer, Nathalie Daude, Lyudmyla Dorosh, Ze-Lin Fu, Charles E. Mays, Hristina Gapeshina, Serene L. Wohlgemuth, Claudia Y. Acevedo-Morantes, Jing Yang, Neil R. Cashman, Michael B. Coulthart, Dawn M. Pearson, Jeffrey T. Joseph, Holger Wille, Jiri G. Safar, Gerard H. Jansen, Maria Stepanova, Brian D. Sykes, David Westaway

PLOS Pathogens: published January 16, 2018 | https://doi.org/10.1371/journal.ppat.1006826

STAT3 expression by myeloid cells is detrimental for the T- cell-mediated control of infection with Mycobacterium tuberculosis

Yu Gao, Juan Ignacio Basile, Cajsa Classon, Dolores Gavier-Widen, Akihiko Yoshimura, Berit Carow, Martin E. Rottenberg

PLOS Pathogens: published January 16, 2018 | https://doi.org/10.1371/journal.ppat.1006809

Effect of analytical treatment interruption and reinitiation of antiretroviral therapy on HIV reservoirs and immunologic parameters in infected individuals

Katherine E. Clarridge, Jana Blazkova, Kevin Einkauf, Mary Petrone, Eric W. Refsland, J. Shawn Justement, Victoria Shi, Erin D. Huiting, Catherine A. Seamon, Guinevere Q. Lee, Xu G. Yu, Susan Moir, Michael C. Sneller, Mathias Lichterfeld, Tae-Wook Chun

PLOS Pathogens: published January 11, 2018 | https://doi.org/10.1371/journal.ppat.1006792

Beta HPV38 oncoproteins act with a hit-and-run mechanism in ultraviolet radiation-induced skin carcinogenesis in mice

Daniele Viarisio, Karin Müller-Decker, Rosita Accardi, Alexis Robitaille, Matthias Dürst, Katrin Beer, Lars Jansen, Christa Flechtenmacher, Matthias Bozza, Richard Harbottle, Catherine Voegele, Maude Ardin, Jiri Zavadil, Sandra Caldeira, Lutz Gissmann, Massimo Tommasino

PLOS Pathogens: published January 11, 2018 | https://doi.org/10.1371/journal.ppat.1006783

Continental synchronicity of human influenza virus epidemics despite climactic variation

Jemma L. Geoghegan, Aldo F. Saavedra, Sebastián Duchêne, Sheena Sullivan, Ian Barr, Edward C. Holmes

PLOS Pathogens: published January 11, 2018 | https://doi.org/10.1371/journal.ppat.1006780

Prohibitin plays a critical role in Enterovirus 71 neuropathogenesis

Issac Horng Khit Too, Isabelle Bonne, Eng Lee Tan, Justin Jang Hann Chu, Sylvie Alonso

PLOS Pathogens: published January 11, 2018 | https://doi.org/10.1371/journal.ppat.1006778

Strains of bacterial species induce a greatly varied acute adaptive immune response: The contribution of the accessory genome

Uri Sela, Chad W. Euler, Joel Correa da Rosa, Vincent A. Fischetti

PLOS Pathogens: published January 11, 2018 | https://doi.org/10.1371/journal.ppat.1006726

The potent effect of mycolactone on lipid membranes

Milène Nitenberg, Anaïs Bénarouche, Ofelia Maniti, Estelle Marion, Laurent Marsollier, Julie Géan, Erick J. Dufourc, Jean-François Cavalier, Stéphane Canaan, Agnès P. Girard-Egrot

PLOS Pathogens: published January 10, 2018 | https://doi.org/10.1371/journal.ppat.1006814

Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection

Thamir Alandijany, Ashley P. E. Roberts, Kristen L. Conn, Colin Loney, Steven McFarlane, Anne Orr, Chris Boutell

PLOS Pathogens: published January 8, 2018 | https://doi.org/10.1371/journal.ppat.1006769

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Herpes simplex viruses activate phospholipid scramblase to redistribute phosphatidylserines and Akt to the outer leaflet of the plasma membrane and promote viral entry

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