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måndag 9 mars 2020

COVID-19 nsp15 (6453..6798) endoRNAasi , 346 aminohappoa

  mat_peptide     6453..6798
                     /product="endoRNAse"
                     /note="nsp15; produced by pp1ab only"
                     /protein_id="YP_009725310.1"
                     /calculated_mol_wt=38814
 
 
FEATURES             Location/Qualifiers
     source          1..346
                     /organism="Severe acute respiratory syndrome coronavirus
                     2"
                     /isolate="Wuhan-Hu-1"
                     /host="Homo sapiens"
                     /db_xref="taxon:2697049"
                     /country="China"
                     /collection_date="Dec-2019"
     Protein         1..346
                     /product="endoRNAse"
                     /note="nsp15; produced by pp1ab only"
                     /calculated_mol_wt=38814
     Precursor       1..346
                     /derived_from="YP_009724389.1:6453..6798"
ORIGIN      
        1 slenvafnvv nkghfdgqqg evpvsiinnt vytkvdgvdv elfenkttlp vnvafelwak
       61 rnikpvpevk ilnnlgvdia antviwdykr dapahistig vcsmtdiakk pteticaplt
      121 vffdgrvdgq vdlfrnarng vlitegsvkg lqpsvgpkqa slngvtlige avktqfnyyk
      181 kvdgvvqqlp etyftqsrnl qefkprsqme idflelamde fieryklegy afehivygdf
      241 shsqlgglhl liglakrfke spfeledfip mdstvknyfi tdaqtgsskc vcsvidllld
      301 dfveiiksqd lsvvskvvkv tidyteisfm lwckdghvet fypklq
//
SARS2 Swiss model 
YP_009725310.1 (346 residues)Uridylate-specific endoribonuclease (NendoU/nsp15):
        Mn(2+)-dependent,
        uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to
        the cleaved bond. 


        Experimental structure (PDB 6vww) and 
        several high quality models are available.
         

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