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måndag 9 mars 2020

COVID-19 nsp14 (5926..6452), , Exonukleaasi , 527 aminohappoa


  mat_peptide     5926..6452
                     /product="3'-to-5' exonuclease"
                     /note="nsp14; produced by pp1ab only"
                     /protein_id="YP_009725309.1"
                     /calculated_mol_wt=59816


https://www.ncbi.nlm.nih.gov/protein/YP_009725309.1

FEATURES             Location/Qualifiers
     source          1..527
                     /organism="Severe acute respiratory syndrome coronavirus
                     2"
                     /isolate="Wuhan-Hu-1"
                     /host="Homo sapiens"
                     /db_xref="taxon:2697049"
                     /country="China"
                     /collection_date="Dec-2019"
     Protein         1..527
                     /product="3'-to-5' exonuclease"
                     /note="nsp14; produced by pp1ab only"
                     /calculated_mol_wt=59816
     Precursor       1..527
                     /derived_from="YP_009724389.1:5926..6452"
ORIGIN      
        1 aenvtglfkd cskvitglhp tqapthlsvd tkfkteglcv dipgipkdmt yrrlismmgf
       61 kmnyqvngyp nmfitreeai rhvrawigfd vegchatrea vgtnlplqlg fstgvnlvav
      121 ptgyvdtpnn tdfsrvsakp ppgdqfkhli plmykglpwn vvrikivqml sdtlknlsdr
      181 vvfvlwahgf eltsmkyfvk igpertcclc drratcfsta sdtyacwhhs igfdyvynpf
      241 midvqqwgft gnlqsnhdly cqvhgnahva scdaimtrcl avhecfvkrv dwtieypiig
      301 delkinaacr kvqhmvvkaa lladkfpvlh dignpkaikc vpqadvewkf ydaqpcsdka
      361 ykieelfysy athsdkftdg vclfwncnvd rypansivcr fdtrvlsnln lpgcdggsly
      421 vnkhafhtpa fdksafvnlk qlpffyysds pceshgkqvv sdidyvplks atcitrcnlg
      481 gavcrhhane yrlyldaynm misagfslwv ykqfdtynlw ntftrlq
//
SARS2 SWISS Model 
https://swissmodel.expasy.org/interactive/7BgWuu/models/04 
 Guanine-N7 methyltransferase (ExoN/nsp14):
        Enzyme possessing two
        different activities: an exoribonuclease activity acting on both ssRNA
        and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase
        activity.


        High quality models are available. Hetero-oligomeric complex with nsp10 is
        available in hetero section.
        

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