Pathol Oncol Res. 2016 Oct;22(4):661-6. doi: 10.1007/s12253-016-0080-7. Epub 2016 Jun 10.
Relevance of the Measles Virus Expression in Cancer - an Update.
Abstract
Evidence of an association between classical Hodgkin lymphoma and the measles virus
has previously been presented by our group. Arguments held against our
thesis were reevaluated. Substantiation of a relationship between the measles virus
and additional solid tumors was submitted. Moreover, a pathogenic
pathway was suggested to support a possible contribution of the measles virus to the development of classical Hodgkin lymphoma.
We have chosen to exclude a discussion of measles virotherapy, since this carries distinct implications. We now add new evidence regarding the expression of the measles virus phosphoprotein in a few cancers.
We also suggest a role in this context for atypical measles syndrome in malignant tumors.
Last, we propose a collaboration which may make the best, on the one hand of our cohort of classical Hodgkin lymphoma, half of which carry the measles virus expression in their tumor cells.
The planned study will also look into the patients vaccination records and into a previous history of the measles disease.
On the other hand, cohorts of patients diagnosed with late onset measles will be assessed for the eventual diagnosis of atypical measles syndrome and will be followed up for the subsequent development of a malignant tumor.
We have chosen to exclude a discussion of measles virotherapy, since this carries distinct implications. We now add new evidence regarding the expression of the measles virus phosphoprotein in a few cancers.
We also suggest a role in this context for atypical measles syndrome in malignant tumors.
Last, we propose a collaboration which may make the best, on the one hand of our cohort of classical Hodgkin lymphoma, half of which carry the measles virus expression in their tumor cells.
The planned study will also look into the patients vaccination records and into a previous history of the measles disease.
On the other hand, cohorts of patients diagnosed with late onset measles will be assessed for the eventual diagnosis of atypical measles syndrome and will be followed up for the subsequent development of a malignant tumor.
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