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tisdag 23 december 2014

Ihmisen pegivirus HPgV Argentiinassa

J Med Virol. 2014 Dec;86(12):2076-83. doi: 10.1002/jmv.23918. Epub 2014 Mar 10. Human pegivirus molecular epidemiology in Argentina: potential contribution of Latin American migration to genotype 3 circulation. Trinks J1, Maestri M, Oliveto F, Del Pino N, Weissenbacher M, Torres OW, Oubiña JR.


In order to determine the human pegivirus (HPgV) genotypic diversity in Argentina taking into account the potential contribution of human migration from neighboring countries, samples from 130 Argentine injecting drug users, 116 Argentine- and 50 immigrant-pregnant women were analyzed. HPgV RNA prevalence among human immunodeficiency virus (HIV)-positive injecting drug users was similar to HIV-positive pregnant women, as was the case when comparing HIV-negative injecting drug users and HIV-negative pregnant women (P > 0.05). HPgV genotype 2 (HPgV/2) was prevalent among both Argentine injecting drug users and pregnant women, in contrast to HPgV/3 observed among pregnant women from Latin American countries with predominant indigenous populations and who had experienced their initial sexual intercourses--and possibly their source of infection--in those countries (P < 0.01). In addition, HPgV vertical and horizontal transmission was proven by molecular analysis of E2 gene and construction of identity matrixes with epidemiologically non-related isolates. This study shows that human migration from neighboring Latin American countries with predominant indigenous populations might contribute to HPgV/3 circulation in Argentina. © 2014 Wiley Periodicals, Inc. KEYWORDS:
Argentina; human pegivirus (HPgV); injecting drug users; pregnant women; viral genotypes

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