How Does Glycosylation of Ebola Virus Envelope Proteins Facilitate Immune Evasion?In EBOV, four variants of the envelope glycoprotein are synthesized as a result of transcriptional stuttering or post-translational processing (Figure 1A).
About 25% of transcripts from the GP gene produce the virion-attached or envelope spike GP that is important for entry.
The surface of the envelope GP is covered with N- and O-linked glycans.
Depending on the EBOV species, the envelope GP contains 11–18 N-linked glycan sites.
Furthermore, EBOV GP contains an unstructured ~150-residue mucin-like domain that is heavily modified with O-linked glycans (~80 sites) .
The N-linked glycans are a heterogeneous mixture of ~60 different species of high-mannose, hybrid, and complex oligosaccharides,
while the O-linked glycans consist of primarily smaller trisaccharide structures (core 2) that contain varying amounts of sialic acids .
- Kohdistan nyt pohdinnan MUSIININ kaltaiseen domeeniin. Mikä merkitys sillä virukselle on?
and thought to form an extended structure that provides another glycan layer of protection to the virus.