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onsdag 22 oktober 2014

(PAMP) Tollin kaltaiset reseptorit ,ligandit sijainteineen, adaptorit sijainteineen, solutyypit (Kertausta!)


Summary of known mammalian TLRs


Toll-like receptors bind and become activated by different ligands, which, in turn, are located on different types of organisms or structures. They also have different adapters to respond to activation and are located sometimes at the cell surface and sometimes to internal cell compartments. Furthermore, they are expressed by different types of leucocytes or other cell types:
Receptor Ligand(s)[27] Ligand location[27] Adapter(s) Location Cell types[27]
TLR 1 multiple triacyl lipopeptides Bacteria MyD88/MAL cell surface
TLR 2 multiple glycolipids Bacteria MyD88/MAL cell surface
multiple lipopeptides Bacteria
multiple lipoproteins Bacteria
lipoteichoic acid Gram-positive bacteria
HSP70 Host cells
zymosan (Beta-glucan) Fungi
Numerous others
TLR 3 double-stranded RNA, poly I:C viruses TRIF cell compartment
  • Dendritic cells
  • B lymphocytes
TLR 4 lipopolysaccharide Gram-negative bacteria MyD88/MAL/TRIF/TRAM cell surface
several heat shock proteins Bacteria and host cells
fibrinogen host cells
heparan sulfate fragments host cells
hyaluronic acid fragments host cells
Various opioid drugs
TLR 5 flagellin Bacteria rowspan=2| MyD88 cell surface
  • monocyte/macrophages
  • a subset of dendritic cells
  • Intestinal epithelium
[[profilin[31]]] Toxoplasma gondii
TLR 6 multiple diacyl lipopeptides Mycoplasma MyD88/MAL cell surface
  • monocytes/macrophages
  • Mast cells
  • B lymphocytes
TLR 7 imidazoquinoline small synthetic compounds MyD88 cell compartment
loxoribine (a guanosine analogue)
single-stranded RNA RNA viruses
TLR 8 small synthetic compounds; single-stranded RNA
MyD88 cell compartment
  • monocytes/macrophages
  • a subset of dendritic cells
  • Mast cells
TLR 9 unmethylated CpG Oligodeoxynucleotide DNA Bacteria, DNA viruses MyD88 cell compartment
  • monocytes/macrophages
  • Plasmacytoid dendritic cells[29]
  • B lymphocytes
TLR 10 unknown
unknown  ?
TLR 11 Profilin Toxoplasma gondii[32] MyD88 cell compartment[33]
TLR 12 Profilin Toxoplasma gondii[34] MyD88
  • Neurons[35]
  • plasmacytoid dendritic cells
  • conventional dendritic cells
  • macrophages
TLR 13 [36][37] bacterial ribosomal RNA sequence “CGGAAAGACC” Virus, bacteria MyD88, TAK-1 cell compartment
  • monocytes/macrophages
  • conventional dendritic cells

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